caa a22 4500 397591462 CHVBK 20180308164939.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/jac/37.suppl_A.57 doi (NATIONALLICENCE)oxford-10.1093/jac/37.suppl_A.57 A review of the penetration of sparfloxacin into the lower respiratory tract and sinuses [Elektronische Daten] [R. Wise, D. Honeybourne] There are a number of potential sites of infection in the lower respiratory tract. This review summarises the nature of these sites and the ways in which antibiotic penetration can be studied. The results of a single-dose and a multiple-dose study of the penetration of sparfloxacin into the respiratory tract are also provided. After a single oral dose of sparfloxacin 400 mg or a 400 mg loading dose on day 1 followed by 200 mg daily for 2 days, sparfloxacin concentrations in the bronchial mucosa, epithelial lining fluid and alveolar macrophages were higher than the corresponding concentrations in serum. Compared with other fluoroquinolones, sparfloxacin achieves higher concentrations at these sites. Sparfloxacin diffusion into maxillary sinus mucosa has been studied in patients with chronic maxillary sinusitis undergoing surgery. High concentrations of sparfloxacin were detected in sinus mucosa 2 to 5 h after administration of a single dose of sparfloxacin 200 or 400 mg. © 1996 The British Society for Antimicrobial Chemotherapy Articles nationallicence Wise R. Department of Medical Microbiology Birmingham, UK aut Honeybourne D. Respiratory Medicine, City Hospital NHS Trust Birmingham, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-05), 57-63 0305-7453 37<57 1996 37 jac https://doi.org/10.1093/jac/37.suppl_A.57 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.suppl_A.57 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wise R. Department of Medical Microbiology Birmingham, UK aut NATIONALLICENCE 700 1- Honeybourne D. Respiratory Medicine, City Hospital NHS Trust Birmingham, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-05), 57-63 0305-7453 37<57 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford