caa a22 4500 397591489 CHVBK 20180308164940.0 cr unu---uuuuu 161202e199602 xx s 000 0 eng 10.1093/jac/37.2.383 doi (NATIONALLICENCE)oxford-10.1093/jac/37.2.383 Lack of interaction between valaciclovir, the L-valyl ester of acyclovir, and Maalox antacid [Elektronische Daten] [Florence de Bony, Roselyne Bidault, Richard Peck, John Posner] Valaciclovir is rapidly and extensively converted to acyclovir. In this study we investigated the potential interaction between oral valaciclovir and Maalox. On each of three occasions 18 healthy volunteers received a single oral dose of 1000 mg valaciclovir, or 30 mL Maalox 65 min after valaciclovir administration, or 30 mL Maalox 30 min before valaciclovir. Acyclovir plasma concentrations and pharmacokinetic parameters were not significantly affected by administration of Maalox before or after valaciclovir. Therefore, there is no need for restriction of valaciclovir dosing in patients receiving antacid medication. © 1996 The British Society for Antimicrobial Chemotherapy Brief reports nationallicence de Bony Florence Department of Clinical Pharmacology, Laboratories Wellcome 20 rue Rouget de Lisle, 92 442 Issy les Moulineaux Cedex, France aut Bidault Roselyne Department of Clinical Pharmacology, Laboratories Wellcome 20 rue Rouget de Lisle, 92 442 Issy les Moulineaux Cedex, France aut Peck Richard Department of Clinical Pharmacology, The Wellcome Research Laboratories Langley Court, Beckenham, Kent BR3 3BS, UK aut Posner John Department of Clinical Pharmacology, The Wellcome Research Laboratories Langley Court, Beckenham, Kent BR3 3BS, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/2(1996-02), 383-387 0305-7453 37:2<383 1996 37 jac https://doi.org/10.1093/jac/37.2.383 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.2.383 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Bony Florence Department of Clinical Pharmacology, Laboratories Wellcome 20 rue Rouget de Lisle, 92 442 Issy les Moulineaux Cedex, France aut NATIONALLICENCE 700 1- Bidault Roselyne Department of Clinical Pharmacology, Laboratories Wellcome 20 rue Rouget de Lisle, 92 442 Issy les Moulineaux Cedex, France aut NATIONALLICENCE 700 1- Peck Richard Department of Clinical Pharmacology, The Wellcome Research Laboratories Langley Court, Beckenham, Kent BR3 3BS, UK aut NATIONALLICENCE 700 1- Posner John Department of Clinical Pharmacology, The Wellcome Research Laboratories Langley Court, Beckenham, Kent BR3 3BS, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/2(1996-02), 383-387 0305-7453 37:2<383 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford