caa a22 4500 397591527 CHVBK 20180308164940.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/jac/38.3.543 doi (NATIONALLICENCE)oxford-10.1093/jac/38.3.543 Mutations in the gyrA and grlA genes of quinolone-resistant clinica isolates of methicillin-resistant Staphylococcus aureus [Elektronische Daten] [Masahiro Takahata, Minoru Yonezawa, Sumiko Kurose, Naoko Futakuchi, Nobuyi Matsubara, Yasuo Watanabe, Hirokazu Narita] The mutations in the quinolone-resistance determining regions (QRDR) of the gyrA, gyrB and grlA genes and in the norA gene from five clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) were examined by DNA sequencing. The mutation from Ser84 to Leu in GyrA was associated with relatively high-level resistance to quinolones, whereas the mutation from Glu88 to Gly or Lys in GyrA was associated with low-level resistance to quinolones. Mutations of the grlA gene were observed at codon 80 (Ser80) or 84 (Glu84), independent of the mutations of gyrA. No mutations were observed in either the gvrB or norA genes. © 1996 The British Society for Antimicrobial Chemotherapy Brief reports nationallicence Takahata Masahiro Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut Yonezawa Minoru Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut Kurose Sumiko Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut Futakuchi Naoko Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut Matsubara Nobuyi Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut Watanabe Yasuo Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut Narita Hirokazu Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 543-546 0305-7453 38:3<543 1996 38 jac https://doi.org/10.1093/jac/38.3.543 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.3.543 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takahata Masahiro Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut NATIONALLICENCE 700 1- Yonezawa Minoru Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut NATIONALLICENCE 700 1- Kurose Sumiko Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut NATIONALLICENCE 700 1- Futakuchi Naoko Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut NATIONALLICENCE 700 1- Matsubara Nobuyi Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut NATIONALLICENCE 700 1- Watanabe Yasuo Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut NATIONALLICENCE 700 1- Narita Hirokazu Research Laboratories, Toyama Chemical Co., Ltd., 2-4-1 Shimookui, Toyama, 930, Japan aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 543-546 0305-7453 38:3<543 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford