caa a22 4500 397591535 CHVBK 20180308164940.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/jac/38.5.877 doi (NATIONALLICENCE)oxford-10.1093/jac/38.5.877 Lack of effect of fluconazole on the pharmacokinetics of rifampicin in AIDS patients [Elektronische Daten] To determine the pharmacokinetic properties of ciprofloxacin in the critically ill, we studied seven mechanically ventilated patients with pneumonia during entcral feedings. Subjects received ciprofloxacin 750 mg every 12 h via nasogastric tube and serial serum drug concentrations were measured after the first and fourth dose. After the initial dose, the maximum serum concentration ranged from 1.24-3.06 mg/L, and the area under the time curve from 0-12 h ranged from 3.2-19.65 mg.h/L. Similar levels were noted after dose four. Gastrointestinal absorption of ciprofloxacin in tube fed critically ill patients was decreased, but well above MIC values for many pathogenic bacteria. © 1996 by the British Society for Antimicrobial Chemotherapy Brief reports nationallicence Jaruratanasirikul Sutep Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla 90112, Thailand Kleepkaew Anun Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla 90112, Thailand Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 877-880 0305-7453 38:5<877 1996 38 jac https://doi.org/10.1093/jac/38.5.877 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.5.877 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jaruratanasirikul Sutep Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla 90112, Thailand NATIONALLICENCE 700 1- Kleepkaew Anun Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkla 90112, Thailand NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 877-880 0305-7453 38:5<877 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford