caa a22 4500 397591578 CHVBK 20180308164940.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/jac/37.suppl_B.87 doi (NATIONALLICENCE)oxford-10.1093/jac/37.suppl_B.87 David Griffiths Paul Virology Department, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, UK Herpesviruses and AIDS [Elektronische Daten] [Paul David Griffiths] Herpesviruses and retroviruses are distinct taxonomically, yet have the potential for multiple bidirectional interactions. In vitro, these interactions have largely been studied in terms of herpesvirus up-regulation of HIV genome expression and/or transmissibility. This can be demonstrated in vitro through experiments showing transactivation, CD4 up-regulation, Fc receptor induction, pseudotype formation, cytokine production, and antigen presentation. In addition, once HIV has induced immunosuppression several herpesviruses can reactivate, and so cause disease in their own right. The in-vivo correlates of these phenomena are difficult to study in humans but evidence is reviewed to support the concept that herpesviruses may be activating HIV, so that potential clinical benefit could be obtained through the use of antiviral drugs active against herpesviruses. Whether the clinical benefits seen in particular trials could be ascribed to inhibition of herpesvirus disease, or to herpesvirus infection driving HIV pathogenesis, remains a controversial area. © 1996 The British Society for Antimicrobial Chemotherapy Articles nationallicence Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-05), 87-95 0305-7453 37<87 1996 37 jac https://doi.org/10.1093/jac/37.suppl_B.87 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.suppl_B.87 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- David Griffiths Paul Virology Department, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, UK NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-05), 87-95 0305-7453 37<87 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford