caa a22 4500 397591608 CHVBK 20180308164940.0 cr unu---uuuuu 161202e199610 xx s 000 0 eng 10.1093/jac/38.4.719 doi (NATIONALLICENCE)oxford-10.1093/jac/38.4.719 Kill kinetics of antimicrobial agents against Helicobacter pylori [Elektronische Daten] [R. K. Flamm, J. Beyer, S. K. Tanaka, J. Clement] We evaluated the activity of clarithromycin, 14-OH clarithromycin, amoxycillin, bismuth, metronidazole and ciprofloxacin against six strains of Helicobacter pylori to determine if there were differences in response to these antimicrobial agents during growth in vitro. Clarithromycin and its 14-hydroxy-metabolite exhibited an early bactericidal activity with at least a 3 log10 reduction after 2-8 h incubation. Exposure to bismuth, ciprofloxacin and metronidazole resulted in a > 3 log reduction by 24 h with the greatest decrease in viability occurring between 8 and 24 h. The viable count of three strains was reduced by a 1-2 log10 after 24 h exposure to amoxycillin and by a > 3 log10 after 48 h. © 1995 The British Society for Antimicrobial Chemotherapy Brief reports nationallicence Flamm R. K. Abbott Laboratories, Anti-infective Research Division of Pharmaceutical Discovery, D47T-AP3, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA aut Beyer J. Abbott Laboratories, Anti-infective Research Division of Pharmaceutical Discovery, D47T-AP3, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA aut Tanaka S. K. Abbott Laboratories, Anti-infective Research Division of Pharmaceutical Discovery, D47T-AP3, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA aut Clement J. Abbott Laboratories, Anti-infective Research Division of Pharmaceutical Discovery, D47T-AP3, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/4(1996-10), 719-725 0305-7453 38:4<719 1996 38 jac https://doi.org/10.1093/jac/38.4.719 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.4.719 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Flamm R. K. Abbott Laboratories, Anti-infective Research Division of Pharmaceutical Discovery, D47T-AP3, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA aut NATIONALLICENCE 700 1- Beyer J. Abbott Laboratories, Anti-infective Research Division of Pharmaceutical Discovery, D47T-AP3, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA aut NATIONALLICENCE 700 1- Tanaka S. K. Abbott Laboratories, Anti-infective Research Division of Pharmaceutical Discovery, D47T-AP3, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA aut NATIONALLICENCE 700 1- Clement J. Abbott Laboratories, Anti-infective Research Division of Pharmaceutical Discovery, D47T-AP3, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/4(1996-10), 719-725 0305-7453 38:4<719 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford