caa a22 4500 397591632 CHVBK 20180308164940.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/jac/37.5.911 doi (NATIONALLICENCE)oxford-10.1093/jac/37.5.911 Antimicrobial activities in vitro and in vivo of transition element complexes containing gold(I) and osmium(VI) [Elektronische Daten] [Amanda M. Elsome, Jeremey M. T. Hamilton-Miller, William Brumfitt, William C. Noble] Metal compounds have been used as antibacterial agents for centuries. The in-vitro activity of two metal containing complexes, one gold, the other osmium, was investigated using a panel of clinically isolated bacteria and Candida albicans. Twenty strains of each organism were used and MIC and MBC values determined using the agar plate dilution method. Protein binding effects on the activity of the compounds were also investigated using media supplemented with 5% human blood. In-vivo activity of the two compounds was subsequently determined in a hairless-obese mouse skin-surface activity model. Both compounds were highly active against the Gram-positive organisms and Candida albicans in vitro. The gold compound had some Gram-negative activity but the osmium complex was inactive against these organisms. Both were extensively protein bound. In the in-vivo experiment the gold compound achieved a 2-3 log reduction for all the test organisms and was at least as good as or superior to mupirocin in its eradication rate. The osmium compound was inactive. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Elsome Amanda M. Johnson Matthey Technology Centre, Biomedical Department, Blonnts Court Sonning Common, Reading, RG4 9NH, UK aut Hamilton-Miller Jeremey M. T. Royal Free Hospital School of Medicine, Department of Medical Microbiology Pond Street, London, NW3 2QG, UK aut Brumfitt William Royal Free Hospital School of Medicine, Department of Medical Microbiology Pond Street, London, NW3 2QG, UK aut Noble William C. Department of Microbial Diseases, St. Thomas Hospital UMDS, St. John's Institute of Dermatology Lambeth Palace Road, London, SE1 7EH, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/5(1996-05), 911-918 0305-7453 37:5<911 1996 37 jac https://doi.org/10.1093/jac/37.5.911 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.5.911 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Elsome Amanda M. Johnson Matthey Technology Centre, Biomedical Department, Blonnts Court Sonning Common, Reading, RG4 9NH, UK aut NATIONALLICENCE 700 1- Hamilton-Miller Jeremey M. T. Royal Free Hospital School of Medicine, Department of Medical Microbiology Pond Street, London, NW3 2QG, UK aut NATIONALLICENCE 700 1- Brumfitt William Royal Free Hospital School of Medicine, Department of Medical Microbiology Pond Street, London, NW3 2QG, UK aut NATIONALLICENCE 700 1- Noble William C. Department of Microbial Diseases, St. Thomas Hospital UMDS, St. John's Institute of Dermatology Lambeth Palace Road, London, SE1 7EH, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/5(1996-05), 911-918 0305-7453 37:5<911 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford