caa a22 4500 397591640 CHVBK 20180308164940.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/jac/37.suppl_A.19 doi (NATIONALLICENCE)oxford-10.1093/jac/37.suppl_A.19 Comparative in-vitro activity of sparfloxacin against genital pathogens [Elektronische Daten] [Evelio J. Perea, Javier Aznar, Mercedes C. Garcia-Iglesias, Alvaro Pascual] The in-vitro activity of sparfloxacin against four pathogens commonly implicated in genital infections was compared with that of a number of other commonly administered antimicrobials. Sparfloxacin demonstrated excellent activity against Neisseria gonorrhoeae (MIC range of ≤0.0002−5 mg/L for β-lactamase producing strains, and ≤0.0002−0.03 mg/L for non-β-lactamase producing strains). This activity was similar to that of lomefloxacin and ciprofloxacin and was greater than that of ofloxacin. Sparfloxacin was more active against Ureaplasma urealyticum (MIC90 1 mg/L). than the other three quinolones (MIC90 4 mg/L). Sparfloxacin was much more active against Mycoplasma hominis (MIC90 0.06 mg/L) than the other quinolones (MIC90 1 mg/L). Sparfloxacin showed the most potent inhibitory and bactericidal activity of the quinolones against Chlamydia trachomatis with MIC and MBC of 0.06 mg/L (ofloxacin MIC and MBC 1 mg/L; ciprofloxacin and lomefloxacin MIC and MBC 2 mg/L). The results of this study and others performed by workers using different methods are consistently similar. Since sparfloxacin has broad activity against pathogens implicated in genital infections it may be a good therapeutic alternative for these syndromes. © 1996 The British Society for Antimicrobial Chemotherapy Articles nationallicence Perea Evelio J. Department of Microbiology, University of Seville, Apartado 914, Seville 41080, Spain aut Aznar Javier Department of Microbiology, University of Seville, Apartado 914, Seville 41080, Spain aut Garcia-Iglesias Mercedes C. Department of Microbiology, University of Seville, Apartado 914, Seville 41080, Spain aut Pascual Alvaro Department of Microbiology, University of Seville, Apartado 914, Seville 41080, Spain aut Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-05), 19-25 0305-7453 37<19 1996 37 jac https://doi.org/10.1093/jac/37.suppl_A.19 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.suppl_A.19 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Perea Evelio J. Department of Microbiology, University of Seville, Apartado 914, Seville 41080, Spain aut NATIONALLICENCE 700 1- Aznar Javier Department of Microbiology, University of Seville, Apartado 914, Seville 41080, Spain aut NATIONALLICENCE 700 1- Garcia-Iglesias Mercedes C. Department of Microbiology, University of Seville, Apartado 914, Seville 41080, Spain aut NATIONALLICENCE 700 1- Pascual Alvaro Department of Microbiology, University of Seville, Apartado 914, Seville 41080, Spain aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-05), 19-25 0305-7453 37<19 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford