caa a22 4500 397591756 CHVBK 20180308164940.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/jac/38.5.777 doi (NATIONALLICENCE)oxford-10.1093/jac/38.5.777 Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994 [Elektronische Daten] [R. H. Enting, L. Spanjaard, D. van de Beek, E. F. Hensen, J. de Gans, J. Dankert] The increasing antimicrobial resistance among pathogens frequently isolated from patients with bacterial meningitis formed the rationale to perform a surveillance study to determine the prevalence of resistance in The Netherlands. Haemophilus influenzae strains (n=316) isolated from cerebrospinal fluid (CSF), 1125 meningococcal strains isolated from blood or CSF and 398 pneumococcal strains isolated from CSF in 1993 and 1994 were tested by the Etest for susceptibility to commonly prescribed antibiotics for the treatment of community-acquired meningitis. In H. influenzae strains ampicillin-resistance occurred in 7.0%, resistance to chloramphenicol in 2.2%, and resistance to both antibiotics in 0.9%. The prevalence of intermediate penicillin-resistance in meningococci was 3.3%. Resistance to rifampicin was rarely found (0.1%). Intermediate penicillin-resistance in pneumococci was found in only 0.5% of isolates. All 1839 isolates were susceptible to ceftriaxone. Based on these results, we conclude that empirical therapy of childhood community-acquired bacterial meningitis with amoxycillin and chloram phenicol is no longer justified in children who have not been vaccinated against H. influenzae type b. In vaccinated or older children and adults, amoxycillin is a rational choice for empirical treatment of meningitis. The prophylactic use of rifampicin in contacts of patients with meningococcal disease is still applicable. © 1996 by the British Society for Antimicrobial Chemotherapy Original articles nationallicence Enting R. H. Department of Neurology H2-214, Academic Medical Center Meibergdreef 9, 1105 AZ Amsterdam Spanjaard L. The Netherlands Reference Laboratory for Bacterial Meningitis Amsterdam, The Netherlands aut van de Beek D. Department of Neurology H2-214, Academic Medical Center Meibergdreef 9, 1105 AZ Amsterdam aut Hensen E. F. Department of Neurology H2-214, Academic Medical Center Meibergdreef 9, 1105 AZ Amsterdam aut de Gans J. Department of Neurology H2-214, Academic Medical Center Meibergdreef 9, 1105 AZ Amsterdam aut Dankert J. The Netherlands Reference Laboratory for Bacterial Meningitis Amsterdam, The Netherlands aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 777-786 0305-7453 38:5<777 1996 38 jac https://doi.org/10.1093/jac/38.5.777 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.5.777 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Enting R. H. Department of Neurology H2-214, Academic Medical Center Meibergdreef 9, 1105 AZ Amsterdam NATIONALLICENCE 700 1- Spanjaard L. The Netherlands Reference Laboratory for Bacterial Meningitis Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van de Beek D. Department of Neurology H2-214, Academic Medical Center Meibergdreef 9, 1105 AZ Amsterdam aut NATIONALLICENCE 700 1- Hensen E. F. Department of Neurology H2-214, Academic Medical Center Meibergdreef 9, 1105 AZ Amsterdam aut NATIONALLICENCE 700 1- de Gans J. Department of Neurology H2-214, Academic Medical Center Meibergdreef 9, 1105 AZ Amsterdam aut NATIONALLICENCE 700 1- Dankert J. The Netherlands Reference Laboratory for Bacterial Meningitis Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 777-786 0305-7453 38:5<777 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford