caa a22 4500 397591810 CHVBK 20180308164940.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/jac/38.5.771 doi (NATIONALLICENCE)oxford-10.1093/jac/38.5.771 The synergic effects of quinolones and oral cephem antibiotics on Serratia marcescens [Elektronische Daten] [Masako Otsuki, Takeshi Nishino] The in-vitro effects of new quinolones and oral cephem antibiotics in various combinations on 26 strains of clinically isolated Serratia marcescens were assessed. The in-vitro activities of ofloxacin and ciprofloxacin in combination with either cefpodoxime or cefcamate were evaluated by the chequerboard titration method. These combinations showed synergistic and additive effects against most of the S. marcescens tested but no antagonism was observed. Time-kill experiments performed with two representative isolates of S. marcescens showed synergic effects with respect to the kill rates, when concentrations of quinolones and β-lactam antibiotics, exhibiting bacteriostatic effects were combined. Exposure of S. marcescens to ciprofloxacin before the addition of cefpodoxime had no influence on the combination effect. When cefpodoxime was added first, however, the bactericidal effect was reduced. The induction of β-lactamase by cefmetazole was enhanced by the combination of ciprofloxacin and cefmetazole. These results suggest that the synergic effects observed between new quinolones and cephem antibiotics are due to the stimulation of incorporation of cephems by combination with quinolones. © 1996 by the British Society for Antimicrobial Chemotherapy Original articles nationallicence Otsuki Masako Department of Microbiology, Kyoto Pharmaceutical University, 5-Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607, Japan Nishino Takeshi Department of Microbiology, Kyoto Pharmaceutical University, 5-Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607, Japan aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 771-776 0305-7453 38:5<771 1996 38 jac https://doi.org/10.1093/jac/38.5.771 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.5.771 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Otsuki Masako Department of Microbiology, Kyoto Pharmaceutical University, 5-Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607, Japan NATIONALLICENCE 700 1- Nishino Takeshi Department of Microbiology, Kyoto Pharmaceutical University, 5-Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607, Japan aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 771-776 0305-7453 38:5<771 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford