caa a22 4500 39759190X CHVBK 20180308164941.0 cr unu---uuuuu 161202e199612 xx s 000 0 eng 10.1093/jac/38.6.1041 doi (NATIONALLICENCE)oxford-10.1093/jac/38.6.1041 The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei [Elektronische Daten] [Simon L. Croft, Diane Snowdon, Vanessa Yardley] The in-vitro activities of four anticancer alkyllysophospholipids, ET-18-OCH3 (edelfosine), hexadecylphosphocholine (miltefosine), ilmofosine and SRI 62-834, were determined with ED50 values for Leishmania donovani and Trypanosoma cruzi amastigotes between 0.2 and 5.0 μM and for Trypanosoma brucei trypomastigotes between 7.0 and 50.8 μM. In BALB/c mice miltefosine and ilmofosine were the most active compounds with ED50 values of 2.9 and 14.5 mg/kg × 5 doses against L. donovani and a suppressive effect on T. cruzi infections at 30 mg/kg × 5 doses. © 1996 by the British Society for Antimicrobial Chemotherapy Original articles nationallicence Croft Simon L. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK aut Snowdon Diane Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK aut Yardley Vanessa Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/6(1996-12), 1041-1047 0305-7453 38:6<1041 1996 38 jac https://doi.org/10.1093/jac/38.6.1041 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.6.1041 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Croft Simon L. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK aut NATIONALLICENCE 700 1- Snowdon Diane Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK aut NATIONALLICENCE 700 1- Yardley Vanessa Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/6(1996-12), 1041-1047 0305-7453 38:6<1041 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford