caa a22 4500 397591926 CHVBK 20180308164941.0 cr unu---uuuuu 161202e199606 xx s 000 0 eng 10.1093/jac/37.6.1165 doi (NATIONALLICENCE)oxford-10.1093/jac/37.6.1165 Amphotericin B intralipid formulation: stability and particle size [Elektronische Daten] [J. Y. Ranchère, J. F. Latour, C. Fuhrmann, C. Lagallarde, F. Loreuil] Amphotencin B remains the drug of choice for treating systemic fungal infections, although toxicity limits its clinical use. Some studies reported the use of Intralipid deoxycholate amphotericin B as an alternative delivery system. An in-vitro study was performed to assess the compatibility of deoxycholate amphotericin B in Intralipid. With two types of dilution of deoxycholate amphotericin B (in 5% dextrose and Intralipid or in Intralipid alone) the solution stability was not constant with a clear yellow precipitate. We observed an increase in the size of the particles (1.5-4-fold). In light of these results Intralipid deoxycholate amphotericin B should not be routinely administered. © 1996 The British Society for Antimicrobial Chemotherapy Brief reports nationallicence Ranchère J. Y. Department of Anesthesiology; Cancer Center Léon Bérard 69008 Lyon, France aut Latour J. F. Department of Pharmacy, Cancer Center Léon Bérard 69008 Lyon, France aut Fuhrmann C. Department of Microbiology, Cancer Center Léon Bérard 69008 Lyon, France aut Lagallarde C. Kabi-Pharmacia, St Quentin en Yvelines Boulogne-Billancourt, France aut Loreuil F. Laboratories Bruneau Boulogne-Billancourt, France aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/6(1996-06), 1165-1169 0305-7453 37:6<1165 1996 37 jac https://doi.org/10.1093/jac/37.6.1165 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.6.1165 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ranchère J. Y. Department of Anesthesiology; Cancer Center Léon Bérard 69008 Lyon, France aut NATIONALLICENCE 700 1- Latour J. F. Department of Pharmacy, Cancer Center Léon Bérard 69008 Lyon, France aut NATIONALLICENCE 700 1- Fuhrmann C. Department of Microbiology, Cancer Center Léon Bérard 69008 Lyon, France aut NATIONALLICENCE 700 1- Lagallarde C. Kabi-Pharmacia, St Quentin en Yvelines Boulogne-Billancourt, France aut NATIONALLICENCE 700 1- Loreuil F. Laboratories Bruneau Boulogne-Billancourt, France aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/6(1996-06), 1165-1169 0305-7453 37:6<1165 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford