caa a22 4500 397592051 CHVBK 20180308164941.0 cr unu---uuuuu 161202e199604 xx s 000 0 eng 10.1093/jac/37.4.759 doi (NATIONALLICENCE)oxford-10.1093/jac/37.4.759 Characterization of antiviral activity of a sesquiterpene, triptofordin C-2 [Elektronische Daten] [Kyoko Hayashi, Toshimitsu Hayashi, Kunie Ujita, Yoshihisa Takaishi] The activities of 13 sesquiterpenes isolated from Tripterygium wilfordii Hook fil. var. regelii Makino were studied against herpes simplex virus type 1 (HSV-1) in vitro. Among these compounds, only triptofordin C-2 showed a selectivity index of more than 10. The compound, which could also inhibit the replication of human cytomegalovirus (HCMV), did not affect either adsorption or penetration of HSV-1 to host cells, but showed moderate virucidal activity against several enveloped viruses including HSV-1, HCMV, measles virus and influenza A virus. Triptofordin C-2 suppressed viral protein synthesis of infected cells when added at early steps of HSV-1 replication and exerted inhibition of translation of the transcripts of the immediate early genes. When acyclovir and triptofordin C-2 were evaluated in combination for antiviral activity against HSV-1 replication, additive antiviral effects were observed for this virus. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Hayashi Kyoko Department of Virology Shomachi 1-78, Tokushima 770, Japan aut Hayashi Toshimitsu Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University 2630 Sugitani, Toyama 930-01 Japan aut Ujita Kunie Faculty of Pharmaceutical Sciences, University of Tokushima Shomachi 1-78, Tokushima 770, Japan aut Takaishi Yoshihisa Faculty of Pharmaceutical Sciences, University of Tokushima Shomachi 1-78, Tokushima 770, Japan aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 759-768 0305-7453 37:4<759 1996 37 jac https://doi.org/10.1093/jac/37.4.759 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.4.759 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hayashi Kyoko Department of Virology Shomachi 1-78, Tokushima 770, Japan aut NATIONALLICENCE 700 1- Hayashi Toshimitsu Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University 2630 Sugitani, Toyama 930-01 Japan aut NATIONALLICENCE 700 1- Ujita Kunie Faculty of Pharmaceutical Sciences, University of Tokushima Shomachi 1-78, Tokushima 770, Japan aut NATIONALLICENCE 700 1- Takaishi Yoshihisa Faculty of Pharmaceutical Sciences, University of Tokushima Shomachi 1-78, Tokushima 770, Japan aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 759-768 0305-7453 37:4<759 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford