caa a22 4500 397592124 CHVBK 20180308164941.0 cr unu---uuuuu 161202e199608 xx s 000 0 eng 10.1093/jac/38.2.183 doi (NATIONALLICENCE)oxford-10.1093/jac/38.2.183 Characterization of an inhibitor-resistant enzyme IRT-2 derived from TEM-2 β-lactamase produced by Proteus mirabilis strains [Elektronische Daten] [L. Bret, C. Chanal, D. Sirot, R. Labia, J. Sirot] Ten clincial isolates of Proteus mirabilis were found to produce an inhibitor-resistant TEM β-lactamase (IRT) in association with a TEM-1 enzyme. The IRT enzyme was derived from TEM-2. The blaIRT gene differs from blaTEM-2 gene by one point mutation which leads to the amino-acid substitution Arg→Ser at position 244, as observed for the original IRT-2 enzyme derived from TEM-1 reported in Escherichia coli. This is the first report of an IRT β-lactamase derived from TEM-2. © 1996 by the British Society for Antimicrobial Chemotherapy Original articles nationallicence Bret L. Laboratoire de Bactériologie, Faculté, Université d' Auvergne 28 Place Henri-Dunant, 63001 Clermont-Ferrand aut Chanal C. Laboratoire de Bactériologie, Faculté, Université d' Auvergne 28 Place Henri-Dunant, 63001 Clermont-Ferrand aut Sirot D. Laboratoire de Bactériologie, Faculté, Université d' Auvergne 28 Place Henri-Dunant, 63001 Clermont-Ferrand aut Labia R. Museum National d' Histoire Naturelle CNRS URA 401, 63 rue Buffon, 75231 Paris Cédex 05, France aut Sirot J. Laboratoire de Bactériologie, Faculté, Université d' Auvergne 28 Place Henri-Dunant, 63001 Clermont-Ferrand aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/2(1996-08), 183-191 0305-7453 38:2<183 1996 38 jac https://doi.org/10.1093/jac/38.2.183 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.2.183 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bret L. Laboratoire de Bactériologie, Faculté, Université d' Auvergne 28 Place Henri-Dunant, 63001 Clermont-Ferrand aut NATIONALLICENCE 700 1- Chanal C. Laboratoire de Bactériologie, Faculté, Université d' Auvergne 28 Place Henri-Dunant, 63001 Clermont-Ferrand aut NATIONALLICENCE 700 1- Sirot D. Laboratoire de Bactériologie, Faculté, Université d' Auvergne 28 Place Henri-Dunant, 63001 Clermont-Ferrand aut NATIONALLICENCE 700 1- Labia R. Museum National d' Histoire Naturelle CNRS URA 401, 63 rue Buffon, 75231 Paris Cédex 05, France aut NATIONALLICENCE 700 1- Sirot J. Laboratoire de Bactériologie, Faculté, Université d' Auvergne 28 Place Henri-Dunant, 63001 Clermont-Ferrand aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/2(1996-08), 183-191 0305-7453 38:2<183 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford