caa a22 4500 397592132 CHVBK 20180308164941.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/jac/38.3.333 doi (NATIONALLICENCE)oxford-10.1093/jac/38.3.333 Safety and efficacy of Intralipid emulsions of amphotericin B [Elektronische Daten] [Theodore M. Sievers, Bernard M. Kubak, Annie Wong-Beringer] To evaluate the clinical role of amphotencin/20% Intralipid emulsions (ILA), we conducted a Medline search of the English literature to locate the relevant case reports and clinical studies involving the use of this formulation. Due to differences in study design and definitions, we applied a set of treatment outcome definitions to determine the clinical efficacy of this treatment modality. Only 37 patients received ILA for the treatment of documented fungal infections Using our definitions, four were considered successfully treated, one improved, two failed, and 30 were unevaluable. While infusion-related adverse events and nephrotoxicity were reportedly reduced with ILA, use of adjunctive therapies and concomitant nephrotoxic agents, and comparisons with high infusion concentrations complicate evaluation. Furthermore, incomplete and conflicting data exist regarding the physiochemical stability of ILA. The currently available data do not support recommendations for the use of this formulation for the treatment of systemic fungal infections. © 1996 The British Society for Antimicrobial Chemotherapy Review nationallicence Sievers Theodore M. Department of Pharmaceutical Services aut Kubak Bernard M. School of Medicine, Division of Infectious Diseases, University of California Los Angeles, 633 Circle Drive South, 140 Hanx Building, Los Angeles, CA 90024, USA aut Wong-Beringer Annie School of Medicine, Division of Infectious Diseases, University of California Los Angeles, 633 Circle Drive South, 140 Hanx Building, Los Angeles, CA 90024, USA aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 333-347 0305-7453 38:3<333 1996 38 jac https://doi.org/10.1093/jac/38.3.333 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.3.333 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sievers Theodore M. Department of Pharmaceutical Services aut NATIONALLICENCE 700 1- Kubak Bernard M. School of Medicine, Division of Infectious Diseases, University of California Los Angeles, 633 Circle Drive South, 140 Hanx Building, Los Angeles, CA 90024, USA aut NATIONALLICENCE 700 1- Wong-Beringer Annie School of Medicine, Division of Infectious Diseases, University of California Los Angeles, 633 Circle Drive South, 140 Hanx Building, Los Angeles, CA 90024, USA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 333-347 0305-7453 38:3<333 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford