caa a22 4500 397592159 CHVBK 20180308164941.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/jac/37.5.943 doi (NATIONALLICENCE)oxford-10.1093/jac/37.5.943 Effect of pentoxifylline on the course of systemic Candida albicans infection in mice [Elektronische Daten] [A. Louie, A. L. Baltch, M. A. Franke, W. J. Ritz, R. P. Smith, J. K. Singh, M. A. Gordon] Pentoxifylline can decrease the production of tumour necrosis factor alpha (TNFα) by endotoxin-stimulated macrophages and may improve survival in animals with overwhelming bacterial sepsis. In this study various doses of pentoxifylline were administered to mice with systemic Candida albicans infection to determine its effect on serum TNFα levels, organ fungal burden, and host survival. Intraperitoneal injections of pentoxifylline at 20 mg/kg every 8 h did not affect these endpoints. However, fungal counts were significantly higher in kidneys of animals that received 30 and 60 mg/kg of pentoxifylline every 8 h when compared to controls. Injection of 60 mg/kg of pentoxifylline at 8 h intervals also significantly shortened mean survival from 5.8 to 3.8 days (P=0.01). Pentoxifylline did not affect peripheral WBC counts, serum TNFα and interleukin-6 levels, or the density of neutrophils in tissues. In vitro, pentoxifylline decreased the production of TNFα by C. albicans-stimulated macrophages in a dose-dependent manner, but only at concentrations greater than 100mg/L. In contrast, pentoxifylline suppressed TNFα production by endotoxin-stimulated macrophages at concentrations as low as 10 mg/L. Thus, higher doses of pentoxifylline are detrimental in systemic C. albicans infection. However, the detrimental effect is not mediated by alterations in serum TNFα or interleukin-6 levels or the aggregation of neutrophils in tissues. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Louie A. Infectious Disease Section, Medical Service Albany, New York 12208, USA aut Baltch A. L. Infectious Disease Section, Medical Service Albany, New York 12208, USA aut Franke M. A. Infectious Disease Section, Medical Service Albany, New York 12208, USA aut Ritz W. J. Infectious Disease Section, Medical Service Albany, New York 12208, USA aut Smith R. P. Infectious Disease Section, Medical Service Albany, New York 12208, USA aut Singh J. K. Pathology Section, Laboratory Service, Stratton Veterans Affairs Medical Center Albany, New York 12208, USA aut Gordon M. A. Mycology Laboratory of the Wadsworth Center for Laboratories and Research, New York State Department of Health Albany, New York 12201, USA aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/5(1996-05), 943-954 0305-7453 37:5<943 1996 37 jac https://doi.org/10.1093/jac/37.5.943 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.5.943 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Louie A. Infectious Disease Section, Medical Service Albany, New York 12208, USA aut NATIONALLICENCE 700 1- Baltch A. L. Infectious Disease Section, Medical Service Albany, New York 12208, USA aut NATIONALLICENCE 700 1- Franke M. A. Infectious Disease Section, Medical Service Albany, New York 12208, USA aut NATIONALLICENCE 700 1- Ritz W. J. Infectious Disease Section, Medical Service Albany, New York 12208, USA aut NATIONALLICENCE 700 1- Smith R. P. Infectious Disease Section, Medical Service Albany, New York 12208, USA aut NATIONALLICENCE 700 1- Singh J. K. Pathology Section, Laboratory Service, Stratton Veterans Affairs Medical Center Albany, New York 12208, USA aut NATIONALLICENCE 700 1- Gordon M. A. Mycology Laboratory of the Wadsworth Center for Laboratories and Research, New York State Department of Health Albany, New York 12201, USA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/5(1996-05), 943-954 0305-7453 37:5<943 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford