caa a22 4500 397592213 CHVBK 20180308164942.0 cr unu---uuuuu 161202e199604 xx s 000 0 eng 10.1093/jac/37.4.783 doi (NATIONALLICENCE)oxford-10.1093/jac/37.4.783 Elimination of bacteraemia after dental extraction: comparison of erythromycin and clindamycin for prophylaxis of infective endocarditis [Elektronische Daten] [G. Hall, C. E. Nord, A. Heimdahl] Erythromycin and cindamycin are currently recommended for antibiotic prophylaxis of infective endocarditis in predisposed patients allergic to penicillin undergoing oral invasive procedures. Thirty-eight healthy patients were randomized to receive either erythromycin (1 g) or clindamycin (0.6 g) orally 1.5 h prior to dental extraction. Blood samples for microbiological investigation were collected before, during and 10 min after surgery and were processed by lysis filtration under anaerobic conditions. The incidence of bacteraemia with viridans streptococci was 79% in the erythromycin group and 74% in the clindamycin group. No statistically significant difference was noted in incidence or magnitude of bacteraemia with viridans streptococci or anaerobic bacteria between the two groups, at any sampling time. Ninety-six aerobic and 133 anaerobic strains recovered from the blood samples were tested for their susceptibility to erythromycin and clindamycin as well as to penicillin V and ampicillin. The antimicrobials were found to be highly active against the majority of bacteria except for some enterococci, staphylococci and veillonella. Protection from endocarditis by prophylaxis with erythromycin or clindamycin must be due to elimination of bacteria at a later stage in the development of the disease, rather than by elimination of bacteria from blood during the short period of postoperative bacteraemia. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Hall G. Department of Oral Surgery; Huddinge University Hospital, Karolinska Institute S-141 86, Sweden aut Nord C. E. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute S- 141 86, Sweden aut Heimdahl A. Department of Oral Surgery; Huddinge University Hospital, Karolinska Institute, S-141 86, Sweden, S- 141 86, Sweden aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 783-795 0305-7453 37:4<783 1996 37 jac https://doi.org/10.1093/jac/37.4.783 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.4.783 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hall G. Department of Oral Surgery; Huddinge University Hospital, Karolinska Institute S-141 86, Sweden aut NATIONALLICENCE 700 1- Nord C. E. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute S- 141 86, Sweden aut NATIONALLICENCE 700 1- Heimdahl A. Department of Oral Surgery; Huddinge University Hospital, Karolinska Institute, S-141 86, Sweden, S- 141 86, Sweden aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 783-795 0305-7453 37:4<783 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford