caa a22 4500 397592345 CHVBK 20180308164942.0 cr unu---uuuuu 161202e199601 xx s 000 0 eng 10.1093/jac/37.1.93 doi (NATIONALLICENCE)oxford-10.1093/jac/37.1.93 In-vitro effects of cefodizime of leucocyte functions and colony formation from granulocyte-monocyte progenitors [Elektronische Daten] [W. S. Shin, C. K. Min, Y. R. Kim, J. H. Yoo, M. W. Kang] Infections in immunocompromised patients are often difficult to treat, even with currently available antimicrobial agents. An understanding of the effects of antibiotic therapy on the host's immune response is therefore important when deciding on the clinical management of such patients. Antimicrobial agents which lack immunodepressive effects and/or potentiate the immune response are the goal of current research into the treatment of infections in immunocompromised patients. The effects of cefodizime (1-250 μg/mL) in vitro on some functional activities of leucocytes and on colony formation by granulocyte monocyte progenitors were studied to investigate the effects of the antibiotic on the host's immune response. A marked enhancement in the lymphocyte transformation reaction was observed in cells exposed to cefodizime. This effect was dose-dependent. Cefodizime had no significant effect on antibody-dependent cell cytotoxicity or on natural killer cell-mediated cytotoxicity. The chemotactic activity of neutrophils was not influenced by the presence of cefodizime (P>0.05). The phagocytic activity of neutrophils was significantly increased by cefodizime (P>0.01). Cefodizime significantly stimulated, in a dose-dependent manner, colony formation by granulocyte-monocyte progenitors (P<0.01). Results suggest that cefodizime has certain stimulatory effects on immunocom petent cells such as enhancing the transformation reaction of lymphocytes, neutrophil phagocytosis and colony formation by granulocyte-monocyte progenitors. Further studies are required to clarify the mechanisms responsible for these effects. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Shin W. S. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea aut Min C. K. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea aut Kim Y. R. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea aut Yoo J. H. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea aut Kang M. W. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/1(1996-01), 93-103 0305-7453 37:1<93 1996 37 jac https://doi.org/10.1093/jac/37.1.93 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.1.93 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shin W. S. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea aut NATIONALLICENCE 700 1- Min C. K. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Y. R. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea aut NATIONALLICENCE 700 1- Yoo J. H. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea aut NATIONALLICENCE 700 1- Kang M. W. Department of Internal Medicine, Catholic University Medical College, Seoul, Korea aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/1(1996-01), 93-103 0305-7453 37:1<93 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford