caa a22 4500 397592396 CHVBK 20180308164942.0 cr unu---uuuuu 161202e199604 xx s 000 0 eng 10.1093/jac/37.4.645 doi (NATIONALLICENCE)oxford-10.1093/jac/37.4.645 A meta-analysis of studies on the safety and efficacy of aminoglycosides given either once daily or as divided doses [Elektronische Daten] [Wendy J. Munckhof, M. Lindsay Grayson, John D. Turnidge] We performed a meta-analysis of randomised clinical studies in which the efficacy and toxicity of the same total daily dose of aminoglycosides administered once-daily was compared with multiple divided daily dosing for treating human infections. Of twenty-eight publications identified from a literature search using Medline 19 publications of 20 study comparisons involving 2881 patients met the criteria for analysis. Netilmicin was investigated in 11 studies, amikacin in seven studies and gentamicin in two studies but no studies of tobramycin met the inclusion criteria. The meta-analysis showed that there was a small, statistically significant difference in clinical efficacy of 3.5% (95% confidence intervals 0.5% to 6.5%, P=0.027) in favour of once-daily administration but no significant differences in bacteriological efficacy or nephrotoxicity were detected. Auditory and vestibular toxicity rates were low for all agents and no differences in these toxicities were identified between once-daily or multiple-dose administration regimens either clinically or by audiometry or electronystagmography. Aminoglycosides can be given once-daily without loss of efficacy or increased toxicity offering greater simplicity and potentially improved cost-effectiveness than can be achieved by giving these drugs in divided doses. © 1996 The British Society for Antimicrobial Chemotherapy Review nationallicence Munckhof Wendy J. Department of Microbiology and Infectious Diseases, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168 Australia aut Grayson M. Lindsay Department of Microbiology and Infectious Diseases, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168 Australia aut Turnidge John D. Department of Microbiology and Infectious Diseases, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168 Australia aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 645-663 0305-7453 37:4<645 1996 37 jac https://doi.org/10.1093/jac/37.4.645 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.4.645 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Munckhof Wendy J. Department of Microbiology and Infectious Diseases, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168 Australia aut NATIONALLICENCE 700 1- Grayson M. Lindsay Department of Microbiology and Infectious Diseases, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168 Australia aut NATIONALLICENCE 700 1- Turnidge John D. Department of Microbiology and Infectious Diseases, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria, 3168 Australia aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 645-663 0305-7453 37:4<645 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford