caa a22 4500 397592418 CHVBK 20180308164942.0 cr unu---uuuuu 161202e199601 xx s 000 0 eng 10.1093/jac/37.1.127 doi (NATIONALLICENCE)oxford-10.1093/jac/37.1.127 Treatment of experimental endocarditis due to multidrug-resistant Enterococcus faecium with clinafloxzcin and penicillin [Elektronische Daten] [Muhammad M. Zaman, David Landman, Sibte Burney, John M. Quale] Clinafloxacin, a new quinolone antibiotic with enhanced activity against Gram-positive bacteria, has demonstrated in-vitro activity against multidrug-resistant Enterococcus faecium, particularly when combined with penicillin. Rabbits with experimental endocarditis due to a multidrug-resistant strain of E. faecium were treated with clinafloxacin and/or penicillin. After three days of therapy, significant reduction of bacterial concentrations were found in vegetations, kidneys, and spleens of animals treated with clinafloxacin. The combination of clinafloxacin and penicillin was significantly better in reducing vegetation bacterial concentrations compared to the other groups (-4.4 log10 cfu/g compared with control). Serum levels of clinafloxacin consistently exceeded the MIC of the strain, and clinafloxacin-resistant isolates could not be detected. Clinafloxacin demonstrated promising activity in vivo against multidrug-resistant E faecium, and further studies are warranted. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Zaman Muhammad M. Department of Medicine (111E), Department of Veterans Affairs Medical Center at Brooklyn, 800 Poly Place, Brooklyn, New York 11209, USA aut Landman David Department of Medicine (111E), Department of Veterans Affairs Medical Center at Brooklyn, 800 Poly Place, Brooklyn, New York 11209, USA aut Burney Sibte Department of Medicine (111E), Department of Veterans Affairs Medical Center at Brooklyn, 800 Poly Place, Brooklyn, New York 11209, USA aut Quale John M. Department of Medicine (111E), Department of Veterans Affairs Medical Center at Brooklyn, 800 Poly Place, Brooklyn, New York 11209, USA aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/1(1996-01), 127-132 0305-7453 37:1<127 1996 37 jac https://doi.org/10.1093/jac/37.1.127 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.1.127 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zaman Muhammad M. Department of Medicine (111E), Department of Veterans Affairs Medical Center at Brooklyn, 800 Poly Place, Brooklyn, New York 11209, USA aut NATIONALLICENCE 700 1- Landman David Department of Medicine (111E), Department of Veterans Affairs Medical Center at Brooklyn, 800 Poly Place, Brooklyn, New York 11209, USA aut NATIONALLICENCE 700 1- Burney Sibte Department of Medicine (111E), Department of Veterans Affairs Medical Center at Brooklyn, 800 Poly Place, Brooklyn, New York 11209, USA aut NATIONALLICENCE 700 1- Quale John M. Department of Medicine (111E), Department of Veterans Affairs Medical Center at Brooklyn, 800 Poly Place, Brooklyn, New York 11209, USA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/1(1996-01), 127-132 0305-7453 37:1<127 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford