caa a22 4500 397592655 CHVBK 20180308164943.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/jac/38.3.475 doi (NATIONALLICENCE)oxford-10.1093/jac/38.3.475 Comparative epileptogenic properties of two monobactam derivatives in C57, Swiss and DBA/2 mice [Elektronische Daten] [A. De Sarro, F. Naccari, C. Imperatore, G. B. De Sarro] The behavioural and electrocortical effects of two monobactam derivatives were studied after intraperitoneal (ip) administration in DBA/2 mice, a strain genetically susceptible to sound-induced seizures, and in C57 and Swiss mice, two strains not prone to seizure. DBA/2 mice were more susceptible than Swiss and C57 mice to seizures induced by aztreonam or carumonam. No significant differences were observed between seizures elicited by aztreonam and carumonam in animals (DBA/2 only) administered intracerebroventricularly or ip. Although the main mechanism for seizure-like activity of monobactams cannot be easily determined, we believe that several mechanisms may be involved. An increased excitation of the central nervous system (CNS) by inhibition of GABA binding to receptors and a slow clearance of aztreonam and carumonam from the CNS may be postulated. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence De Sarro A. Institute of Pharmacology, School of Medicine Piazza XX Settembre 4, 98122 Messina aut Naccari F. Departement of Veterinary Medicine and Pharmacology, School of Veterinary Medicine, University of Messina aut Imperatore C. Institute of Pharmacology, School of Medicine, Piazza XX Settembre 4, 98122 Messina, Italy aut De Sarro G. B. Department of Experimental and Clinical Medicine, School of Medicine, University of Reggio Calabria Italy aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 475-484 0305-7453 38:3<475 1996 38 jac https://doi.org/10.1093/jac/38.3.475 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.3.475 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Sarro A. Institute of Pharmacology, School of Medicine Piazza XX Settembre 4, 98122 Messina aut NATIONALLICENCE 700 1- Naccari F. Departement of Veterinary Medicine and Pharmacology, School of Veterinary Medicine, University of Messina aut NATIONALLICENCE 700 1- Imperatore C. Institute of Pharmacology, School of Medicine, Piazza XX Settembre 4, 98122 Messina, Italy aut NATIONALLICENCE 700 1- De Sarro G. B. Department of Experimental and Clinical Medicine, School of Medicine, University of Reggio Calabria Italy aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 475-484 0305-7453 38:3<475 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford