caa a22 4500 397592663 CHVBK 20180308164943.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/jac/38.1.145 doi (NATIONALLICENCE)oxford-10.1093/jac/38.1.145 Drug delivery system: targeting of pentamidines to specific sites using sugar grafted liposomes [Elektronische Daten] [Goutam Banerjee, Gopa Nandi, Sashi B. Mahato, Anita Pakrashi, Mukul K. Basu] Different sugar-grafted liposomes were prepared and tested against experimental leishmaniasis in vivo using the classical drug pentamidine isethionate and its methoxy derivative. Both the drugs, when encapsulated in sugar-grafted liposomes were found to be more potent in comparison to normal liposome-encapsulated drug or to the free drug. Moreover, the mannose-grafted liposomes were adjudged to be the best in lowering of spleen parasite load in comparison with those bearing glucose or galactose. When encapsulated in mannose-grafted liposomes the therapeutic efficacy of pentamidine isethionate was found to be better than that of its methoxy derivative, although the latter seemed to be less toxic than the pentamidine isethionate itself. © 1996 by the British Society for Antimicrobial Chemotherapy Brief reports nationallicence Banerjee Goutam Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032, India aut Nandi Gopa Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032, India aut Mahato Sashi B. Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032, India aut Pakrashi Anita Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032, India aut Basu Mukul K. Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032, India aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/1(1996-07), 145-150 0305-7453 38:1<145 1996 38 jac https://doi.org/10.1093/jac/38.1.145 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.1.145 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Banerjee Goutam Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032, India aut NATIONALLICENCE 700 1- Nandi Gopa Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032, India aut NATIONALLICENCE 700 1- Mahato Sashi B. Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032, India aut NATIONALLICENCE 700 1- Pakrashi Anita Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032, India aut NATIONALLICENCE 700 1- Basu Mukul K. Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Calcutta-700 032, India aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/1(1996-07), 145-150 0305-7453 38:1<145 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford