caa a22 4500 397592701 CHVBK 20180308164943.0 cr unu---uuuuu 161202e199606 xx s 000 0 eng 10.1093/jac/37.suppl_C.53 doi (NATIONALLICENCE)oxford-10.1093/jac/37.suppl_C.53 Penetration of azithromycin into middle ear effusions in acute and secretory otitis media in children [Elektronische Daten] [J. Pukander, M. Rautianen] In an open-label study, the concentrations of azithromycin in middle ear effusions and plasma were determined in 29 children between 1 and 8 years of age with a diagnosis of either secretory otitis media of at least 1 month's duration or acute otitis media. Azithromycin (lOmg/kg) was administered as a single dose 12, 24 or 48 h before the insertion of tympanostomy tubes to 17 children with secretory otitis media and once daily for 5 days (10 mg/kg on day 1, 5 mg/kg on days 2-5) to 12 children with acute otitis media. In the 16 evaluable patients with secretory otitis media, azithromycin penetrated middle ear effusions, with group mean concentrations approximately two orders of magnitude greater than the concurrent plasma concentrations 12, 24 and 48 h after administration. Similar plasma:effusion ratios were found 24 and 48 h after starting once-daily therapy in 10 evaluable patients with acute otitis media. © 1996 The British Society for Antimicrobial Chemotherapy Articles nationallicence Pukander J. Department of Otolaryngology, University of Tampere Medical School, Box 607, FIN-33101 Tampere, Finland aut Rautianen M. Department of Otolaryngology, University of Tampere Medical School, Box 607, FIN-33101 Tampere, Finland aut Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-06), 53-61 0305-7453 37<53 1996 37 jac https://doi.org/10.1093/jac/37.suppl_C.53 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.suppl_C.53 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pukander J. Department of Otolaryngology, University of Tampere Medical School, Box 607, FIN-33101 Tampere, Finland aut NATIONALLICENCE 700 1- Rautianen M. Department of Otolaryngology, University of Tampere Medical School, Box 607, FIN-33101 Tampere, Finland aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-06), 53-61 0305-7453 37<53 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford