caa a22 4500 397592744 CHVBK 20180308164943.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/jac/38.suppl_A.133 doi (NATIONALLICENCE)oxford-10.1093/jac/38.suppl_A.133 Klugman K. P. MRC/SAIMR/WITS, Pneumococcal Diseases Research Unit, Department of Medical Microbiology and School of Pathology, SA Institute for Medical Research, PO Box 1038, Johannesburg, South Africa The clinical relevance of in-vitro resistance to penicillin, ampicillin, amoxycillin and alternative agents, for the treatment of community-acquired pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis [Elektronische Daten] [K. P. Klugman] The documentation of antimicrobial resistance in respiratory pathogens, contained within the Alexander Project, does not necessarily translate into clinical resistance in the treatment of primary community-acquired pneumonia. There is, in particular, little evidence that penicillin resistance in pneumococci is clinically relevant for the treatment of pneumonia, and there is further evidence that the production of β-lactamase by Haemophilus influenzae may not always be clinically relevant within this setting. β-Lactamase producing H. influenzae and Moraxella catarrhalis should probably be treated with alternative agents when they cause exacerbations of chronic bronchitis. More studies are required to define the clinical breakpoints of macrolide and co-trimoxazole resistance in the treatment of pneumonia. © 1996 The British Society for Antimicrobial Chemotherapy Articles nationallicence Journal of Antimicrobial Chemotherapy Oxford University Press 38(1996-07), 133-140 0305-7453 38<133 1996 38 jac https://doi.org/10.1093/jac/38.suppl_A.133 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.suppl_A.133 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Klugman K. P. MRC/SAIMR/WITS, Pneumococcal Diseases Research Unit, Department of Medical Microbiology and School of Pathology, SA Institute for Medical Research, PO Box 1038, Johannesburg, South Africa NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38(1996-07), 133-140 0305-7453 38<133 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford