caa a22 4500 397592833 CHVBK 20180308164943.0 cr unu---uuuuu 161202e199607 xx s 000 0 eng 10.1093/jac/38.suppl_A.59 doi (NATIONALLICENCE)oxford-10.1093/jac/38.suppl_A.59 Doern G. V. University of Massachusetts Medical Center 55 Lake Avenue North, Worcester, MA 01655-0219, USA aut Antimicrobial resistance among lower respiratory tract isolates of Haemophilus influenzae: results of a 1992-93 Western Europe and USA collaborative surveillance study [Elektronische Daten] [G. V. Doern] During 1992 and 1993, 2718 respiratory tract isolates of Haemophilus influenzae were obtained from two study centres in each of five West European countries and five study centres in the USA. β-Lactamase production was assessed and MICs of 14 antimicrobial agents determined in a single co-ordinating laboratory using a broth microdilution method in Mueller-Hinton-lysed horse blood medium. The prevalence of strains producing β-lactamase varied between 0 and 37.9%. In general, the highest prevalence was in study centres from Spain and the USA with slightly lower rates observed in France and the UK. Only a single confirmed β-lactamase-negative, ampicillin resistant strain was recovered during the entire study. Erythromycin resistance, defined as an MIC of ≥ 4.0 mg/L, was noted in 57.5% of isolates. Among the other antimicrobials tested, resistance rates ≥ 1.0% were observed only with cefaclor (3.7%), chloramphenicol (1.4%) and co-trimoxazole (2.5%). In no case, was the prevalence of resistance or β-lactamase production significantly greater in 1993 than in 1992. © 1996 The British Society for Antimicrobial Chemotherapy Articles nationallicence Journal of Antimicrobial Chemotherapy Oxford University Press 38(1996-07), 59-69 0305-7453 38<59 1996 38 jac https://doi.org/10.1093/jac/38.suppl_A.59 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.suppl_A.59 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Doern G. V. University of Massachusetts Medical Center 55 Lake Avenue North, Worcester, MA 01655-0219, USA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38(1996-07), 59-69 0305-7453 38<59 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford