caa a22 4500 397592906 CHVBK 20180308164944.0 cr unu---uuuuu 161202e199610 xx s 000 0 eng 10.1093/jac/38.4.671 doi (NATIONALLICENCE)oxford-10.1093/jac/38.4.671 ZD0870 treatment of murine candidiasis caused by fluconazole resistant isolates of Candida albicans [Elektronische Daten] [Laura K. Najvar, Ana Correa, Paloma James, Michael F. Luther, John R. Graybill] Mice were infected intravenously with three fluconazole susceptible and ten fluconazole resistant isolates of Candida albicans then treated with escalating doses of 0.25, 0.5, 1, 2.5, 10 and 40 mg/kg/day of the new antifungal triazole, ZDO870, for 10 days. A minimum protective dose of <0.25 mg/kg was determined for infections introduced by the three fluconazole susceptible C. albicans and one of the fluconazole resistant isolates whereas doses ranging from 2.5 to 10 mg/kg/day were required for infections induced by seven of the resistant isolates and ≥ 40 mg/kg/day for the remainder. Thus, infections caused by fluconazole resistant C. albicans may be successfully treated with ZDO870, though higher doses than those used to treat infections due to susceptible yeast may be required. © 1995 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Najvar Laura K. University of Texas Health Science Center, V.A. Hospital, San Antonio, TX, USA aut Correa Ana University of Texas Health Science Center, V.A. Hospital, San Antonio, TX, USA aut James Paloma University of Texas Health Science Center, V.A. Hospital, San Antonio, TX, USA aut Luther Michael F. University of Texas Health Science Center, V.A. Hospital, San Antonio, TX, USA aut Graybill John R. University of Texas Health Science Center, V.A. Hospital, San Antonio, TX, USA aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/4(1996-10), 671-677 0305-7453 38:4<671 1996 38 jac https://doi.org/10.1093/jac/38.4.671 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.4.671 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Najvar Laura K. University of Texas Health Science Center, V.A. Hospital, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Correa Ana University of Texas Health Science Center, V.A. Hospital, San Antonio, TX, USA aut NATIONALLICENCE 700 1- James Paloma University of Texas Health Science Center, V.A. Hospital, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Luther Michael F. University of Texas Health Science Center, V.A. Hospital, San Antonio, TX, USA aut NATIONALLICENCE 700 1- Graybill John R. University of Texas Health Science Center, V.A. Hospital, San Antonio, TX, USA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/4(1996-10), 671-677 0305-7453 38:4<671 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford