caa a22 4500 397593007 CHVBK 20180308164944.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/jac/37.suppl_B.13 doi (NATIONALLICENCE)oxford-10.1093/jac/37.suppl_B.13 The immunopathology of HIV infection [Elektronische Daten] [C. A. Andrews, R. A. Koup] Fourteen years into the global epidemic of the acquired immunodeficiency syndrome, the exact mechanisms by which the human immunodeficiency virus (HIV) causes the destruction of the immune system remain unresolved. Infection with HIV is characterized by both continual virus replication and a vigorous immune response. The length of time from initial infection to the almost inevitable loss of CD4 positive T helper lymphocytes averages 10 years, indicating the dramatic and prolonged interplay of the virus and the host immune response. In this article we discuss many of the leading hypotheses for both direct and indirect mechanisms that have been proposed to explain the loss of CD4 cells. Current evidence suggests strongly that direct infection of CD4 cells is adequate to explain their loss, but that cofactors and indirect mechanisms may contribute to the overall process. This leads to the conclusion that the immunopathology of HIV infection can be most effectively countered by using antiretroviral chemotherapy. © 1996 The British Society for Antimicrobial Chemotherapy Articles nationallicence Andrews C. A. National Hemophilia Foundation 110 Greene Street, Suite 303, New York, NY 10012 aut Koup R. A. Aaron Diamond AIDS Research Center 455 First Avenue, 7th Floor, New York, NY 10016, USA aut Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-05), 13-25 0305-7453 37<13 1996 37 jac https://doi.org/10.1093/jac/37.suppl_B.13 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.suppl_B.13 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Andrews C. A. National Hemophilia Foundation 110 Greene Street, Suite 303, New York, NY 10012 aut NATIONALLICENCE 700 1- Koup R. A. Aaron Diamond AIDS Research Center 455 First Avenue, 7th Floor, New York, NY 10016, USA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-05), 13-25 0305-7453 37<13 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford