caa a22 4500 397593066 CHVBK 20180308164944.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/jac/37.5.871 doi (NATIONALLICENCE)oxford-10.1093/jac/37.5.871 Hoepelman I. M. Department of Medicine, Division of Infectious Diseases and Eijkman Winkler Institute, University Hospital, PO Box 85500, 3508 GA Utrecht, The Netherlands Current therapeutic approaches to cryptosporidiosis in immunocompromised patients [Elektronische Daten] [I. M. Hoepelman] Cryptosporidium parvum is a protozon which can cause a severe debilitating disease in immunocompromised patients. Animal models show that cellular immunity is the most important factor protecting against the development of the disease, but patients with a humoral immune deficiency are also at risk. In HIV-infected patients there is a clear relationship between disease severity and CD4-cell counts. The development of insight into the pathogenesis and of new agents is hampered by the lack of an in-vitro culture system. Prevention is of utmost importance because of the difficulties of therapy and the severity of the clinical disease which can develop. Oocysts are highly resistant to the commonly used disinfectants. HIV-infected patients with cryptosporidiosis not on antiretroviral therapy should commence it. Non-specific therapy with anti-diarrhoeal agents should be instituted. If no effect is seen, therapy with paromomycin 500 mg qds for 2-3 weeks should be started, followed by maintenance therapy with 500 mg bid to prevent a relapse. © 1996 The British Society for Antimicrobial Chemotherapy Review nationallicence Journal of Antimicrobial Chemotherapy Oxford University Press 37/5(1996-05), 871-880 0305-7453 37:5<871 1996 37 jac https://doi.org/10.1093/jac/37.5.871 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.5.871 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hoepelman I. M. Department of Medicine, Division of Infectious Diseases and Eijkman Winkler Institute, University Hospital, PO Box 85500, 3508 GA Utrecht, The Netherlands NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/5(1996-05), 871-880 0305-7453 37:5<871 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford