caa a22 4500 397593074 CHVBK 20180308164944.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/jac/38.3.363 doi (NATIONALLICENCE)oxford-10.1093/jac/38.3.363 Susceptibility testing of Haemophilus influenzae— an international collaborative study in quality assessment [Elektronische Daten] [S. F. Yeo, E. Akalln, S. Arikan, R. Auckenthaler, T. Bergan, K. Dornbusch, A. J. Howard, W. Hryniewicz, R. N. Jones, G. Koupari, N. J. Legakis, J. McLaughlin, C. Ozkuyumcu, A. Percival, I. Phillips, D. Reeves, R. Spencer, R. E. Warren, J. D. Williams] In order to compare the prevalence of antibiotic resistance in different geographical areas, it is necessary to ensure that agreement is achieved between laboratories on the assignment of strains to ‘susceptible' and ‘resistant' categories. An international quality assessment study, involving 15 laboratories in eight countries, was performed to investigate the standard of performance of the susceptibility testing of Haemophilus influenzae. One hundred and fifty strains of H. influenzae were distributed from the London Hospital Medical College (LHMC) to all laboratories who were asked to test the susceptibility of the strains to ampicillin, chloramphenicol, tetracycline, trimethoprim, cephalosporins and ciprofloxacin. Laboratories were also asked to provide the details of methodology to test the susceptibility. Significant discrepancy between the LHMC and the participating laboratories appeared in the detection of resistance to ampicillin (especially β-lactamase-negative strains resistant to ampicillin) as well as the assignment of susceptibility and resistance to chloramphenicol, tetracycline and trimethoprim. Often these reflected the use of inappropriate breakpoints which led to erroneous assignment of susceptibility. Other variations including disc content, medium and supplement, inoculum as well as failure to measure zone sizes properly also led to some repeating anomalies. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Yeo S. F. London Hospital Medical College London, UK aut Akalln E. Haceteppe University Ankara, Turkey aut Arikan S. University Hospital of Geneva Switzerland aut Auckenthaler R. University Hospital of Geneva Switzerland aut Bergan T. University of Oslo Norway aut Dornbusch K. Karolinska Hospital Stockholm, Sweden aut Howard A. J. Bangor Public Health Laboratory Gwynedd, UK aut Hryniewicz W. National Institute of Hygiene Warsaw, Poland aut Jones R. N. University of Iowa Iowa, USA aut Koupari G. University of Athens Medical School Athens, Greece aut Legakis N. J. University of Athens Medical School Athens, Greece aut McLaughlin J. University of New Mexico Medical Center Albuquerque, NM, USA aut Ozkuyumcu C. Haceteppe University Ankara, Turkey aut Percival A. Royal Liverpool University Hospital Liverpool, UK aut Phillips I. United Medical & Dental School London, UK aut Reeves D. Southmead Health Services Bristol, UK aut Spencer R. Public Health Laboratory Bristol, UK aut Warren R. E. Royal Shrewsbury Hospital Shrewsbury, UK aut Williams J. D. London Hospital Medical College London, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 363-386 0305-7453 38:3<363 1996 38 jac https://doi.org/10.1093/jac/38.3.363 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.3.363 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yeo S. F. London Hospital Medical College London, UK aut NATIONALLICENCE 700 1- Akalln E. Haceteppe University Ankara, Turkey aut NATIONALLICENCE 700 1- Arikan S. University Hospital of Geneva Switzerland aut NATIONALLICENCE 700 1- Auckenthaler R. University Hospital of Geneva Switzerland aut NATIONALLICENCE 700 1- Bergan T. University of Oslo Norway aut NATIONALLICENCE 700 1- Dornbusch K. Karolinska Hospital Stockholm, Sweden aut NATIONALLICENCE 700 1- Howard A. J. Bangor Public Health Laboratory Gwynedd, UK aut NATIONALLICENCE 700 1- Hryniewicz W. National Institute of Hygiene Warsaw, Poland aut NATIONALLICENCE 700 1- Jones R. N. University of Iowa Iowa, USA aut NATIONALLICENCE 700 1- Koupari G. University of Athens Medical School Athens, Greece aut NATIONALLICENCE 700 1- Legakis N. J. University of Athens Medical School Athens, Greece aut NATIONALLICENCE 700 1- McLaughlin J. University of New Mexico Medical Center Albuquerque, NM, USA aut NATIONALLICENCE 700 1- Ozkuyumcu C. Haceteppe University Ankara, Turkey aut NATIONALLICENCE 700 1- Percival A. Royal Liverpool University Hospital Liverpool, UK aut NATIONALLICENCE 700 1- Phillips I. United Medical & Dental School London, UK aut NATIONALLICENCE 700 1- Reeves D. Southmead Health Services Bristol, UK aut NATIONALLICENCE 700 1- Spencer R. Public Health Laboratory Bristol, UK aut NATIONALLICENCE 700 1- Warren R. E. Royal Shrewsbury Hospital Shrewsbury, UK aut NATIONALLICENCE 700 1- Williams J. D. London Hospital Medical College London, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 363-386 0305-7453 38:3<363 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford