caa a22 4500 397593155 CHVBK 20180308164944.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/jac/38.5.859 doi (NATIONALLICENCE)oxford-10.1093/jac/38.5.859 Effect of paclitaxel alone or in combination on the intracellular penetration and activity of quinolones in human neutrophils [Elektronische Daten] We evaluated the effect of paclitaxel alone or in combination with cisplatin or doxorubicin, on the intracellular penetration and activity of ciprofloxacin, ofloxacin, levofloxacin and sparfloxacin in human polymorphonuclear leukocytes (PMN). In general, paclitaxel either alone or in combination did not affect the intracellular concentrations of the quinolones evaluated (intracellular to extracellular concentration ratio (C/E) >4). However, at high concentrations (20 mg/L) paclitaxel decreased the penetration of ofloxacin and levofloxacin although the C/E ratios remained higher than 3. Paclitaxel alone or in combination affected neither the production of oxygen radicals by PMN nor the intracellular activity of the quinolones against Staphylococcus aureus. © 1996 by the British Society for Antimicrobial Chemotherapy Brief reports nationallicence García Isabel Department of Microbiology, School of Medicine, Apdo 914, Seville 41080, Spain Pascual Alvaro Department of Microbiology, School of Medicine, Apdo 914, Seville 41080, Spain Salvador Javier Department of Microbiology, School of Medicine, Apdo 914, Seville 41080, Spain Conejo M. Carmen Department of Microbiology, School of Medicine, Apdo 914, Seville 41080, Spain Perea Evelio J. Department of Microbiology, School of Medicine, Apdo 914, Seville 41080, Spain Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 859-863 0305-7453 38:5<859 1996 38 jac https://doi.org/10.1093/jac/38.5.859 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.5.859 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- García Isabel Department of Microbiology, School of Medicine, Apdo 914, Seville 41080, Spain NATIONALLICENCE 700 1- Pascual Alvaro Department of Microbiology, School of Medicine, Apdo 914, Seville 41080, Spain NATIONALLICENCE 700 1- Salvador Javier Department of Microbiology, School of Medicine, Apdo 914, Seville 41080, Spain NATIONALLICENCE 700 1- Conejo M. Carmen Department of Microbiology, School of Medicine, Apdo 914, Seville 41080, Spain NATIONALLICENCE 700 1- Perea Evelio J. Department of Microbiology, School of Medicine, Apdo 914, Seville 41080, Spain NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 859-863 0305-7453 38:5<859 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford