caa a22 4500 397593244 CHVBK 20180308164945.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/jac/37.3.575 doi (NATIONALLICENCE)oxford-10.1093/jac/37.3.575 Efficacy of norfloxacin and doxycycline for treatment of Vibrio cholerae O139 infection [Elektronische Daten] [D. Dutta, S. K. Bhattacharya, M. K. Bhattacharya, A. Deb, M. Deb, B. Manna, A. Moitra, A. K. Mukhopadhyay, G. B. Nair] An open randornised controlled clinical trial with 160 adults with acute watery diarrhoea and severe dehydration compared the efficacy of varying regimens of norfloxacin and doxycycline for the treatment of cholera caused by Vibrio cholerae O139 Bengal. Data were analysed for the 111 patients who were faeces culture positive for V. cholerae O139. In addition to rehydration therapy, 28 patients received 300 mg of doxycycline as a single dose on admission, 26 patients received norfloxacin 400 mg bd for three days, 28 patients received a single dose of 800 mg of norfloxacin and 29 patients received no antibiotic (control group). Patients in the three treatment groups and control group had comparable characteristics on admission. All three treatment groups had reduced stool output, duration of diarrhoea and fluid intake compared with the control group. Multidose norfloxacin treatment significantly reduced stool output, duration of diarrhoea and fluid requirement compared with the other regimens. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Dutta D. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut Bhattacharya S. K. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut Bhattacharya M. K. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut Deb A. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut Deb M. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut Manna B. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut Moitra A. Infectious Diseases Hospital Beliaghata, Calcutta 700 010, India aut Mukhopadhyay A. K. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut Nair G. B. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 575-581 0305-7453 37:3<575 1996 37 jac https://doi.org/10.1093/jac/37.3.575 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.3.575 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dutta D. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut NATIONALLICENCE 700 1- Bhattacharya S. K. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut NATIONALLICENCE 700 1- Bhattacharya M. K. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut NATIONALLICENCE 700 1- Deb A. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut NATIONALLICENCE 700 1- Deb M. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut NATIONALLICENCE 700 1- Manna B. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut NATIONALLICENCE 700 1- Moitra A. Infectious Diseases Hospital Beliaghata, Calcutta 700 010, India aut NATIONALLICENCE 700 1- Mukhopadhyay A. K. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut NATIONALLICENCE 700 1- Nair G. B. National Institute of Cholera and Enteric Diseases P-33, C.I.T. Road, Scheme-XM, Beliaghata, Calcutta 700010 aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 575-581 0305-7453 37:3<575 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford