caa a22 4500 397593252 CHVBK 20180308164945.0 cr unu---uuuuu 161202e199602 xx s 000 0 eng 10.1093/jac/37.2.323 doi (NATIONALLICENCE)oxford-10.1093/jac/37.2.323 Treatment of experimental endocarditis caused by multidrug resistant Enterococcus faecium with ramoplanin and penicillin [Elektronische Daten] [David Landman, John M. Quale, Sibte Burney, Barry Kreiswirth, Barbara M. Willey] Antibiotic resistant strains of enterococci are being isolated with increasing frequency. Effective treatment of infections caused by Enterococcus faecium resistant to ampicillin, vancomycin and aminoglycosides has not been established. We studied the activity of ramoplanin, a new lipoglycopeptide antibiotic, against two strains of multidrug resistant E. faecium. In time kill studies, ramoplanin was bactericidal against both strains, but not in the presence of 50% serum. The combination of ramoplanin and penicillin was bactericidal even in the presence of serum. In rabbits with experimental endocarditis neither penicillin nor ramoplanin significantly reduced vegetation colony counts when given alone, although ramoplanin significantly reduced spleen and kidney bacterial counts of both strains. The combination of ramoplanin plus penicillin resulted in a significant reduction of vegetation bacterial counts (- 3.2 and - 3.7 log10cfu/g for strains VA3 and MMC3, respectively, P<0.01). All spleen cultures and 9 out of 10 kidney cultures from each strain were sterile following combination therapy. While ramoplanin will not be available for parenteral therapy, further research into the development of other lipoglycopeptide antibiotics is warranted. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Landman David Department of Medicine, Department of Veterans Affairs Medical Center Brooklyn, New York aut Quale John M. Department of Medicine, Department of Veterans Affairs Medical Center Brooklyn, New York aut Burney Sibte Department of Medicine, Department of Veterans Affairs Medical Center Brooklyn, New York aut Kreiswirth Barry Public Health Research Institute New York, USA aut Willey Barbara M. Department of Microbiology, Mount Sinai and Princess Margaret Hospitals Toronto, Ontario, Canada aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/2(1996-02), 323-329 0305-7453 37:2<323 1996 37 jac https://doi.org/10.1093/jac/37.2.323 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.2.323 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Landman David Department of Medicine, Department of Veterans Affairs Medical Center Brooklyn, New York aut NATIONALLICENCE 700 1- Quale John M. Department of Medicine, Department of Veterans Affairs Medical Center Brooklyn, New York aut NATIONALLICENCE 700 1- Burney Sibte Department of Medicine, Department of Veterans Affairs Medical Center Brooklyn, New York aut NATIONALLICENCE 700 1- Kreiswirth Barry Public Health Research Institute New York, USA aut NATIONALLICENCE 700 1- Willey Barbara M. Department of Microbiology, Mount Sinai and Princess Margaret Hospitals Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/2(1996-02), 323-329 0305-7453 37:2<323 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford