caa a22 4500 397593260 CHVBK 20180308164945.0 cr unu---uuuuu 161202e199606 xx s 000 0 eng 10.1093/jac/37.6.1051 doi (NATIONALLICENCE)oxford-10.1093/jac/37.6.1051 The use of corticosteroids in the management of bacterial meningitis in adults [Elektronische Daten] [Gregory C. Townsend, W. Michael Scheld] Despite the introduction of newer antimicrobial agents, bacterial meningitis continues to be associated with significant morbidity and mortality. Evidence from in-vitro studies, experimental animal models, and clinical studies indicate that the host inflammatory response is responsible for much of the deleterious consequences of this disease. Thus, there is much interest in the adjunctive use of antiinflammatory agents in the therapy of bacterial meningitis. Although there is considerable evidence from animal models and from clinical trials in children that adjunctive antiinflammatory therapy with corticosteroids is effective in reducing inflammation and in improving long-term outcomes, similar data involving adults are largely lacking. The rationale for the use of corticosteroids in the management of bacterial meningitis, and the applicability to disease in adults, are discussed, and some recommendations for their use in this setting are made. © 1996 The British Society for Antimicrobial Chemotherapy Review nationallicence Townsend Gregory C. Department of Internal Medicine, Division of Infectious Diseases, University of Virginia, Chariottesville, VA 22908, USA aut Scheld W. Michael Department of Internal Medicine, Division of Infectious Diseases, University of Virginia, Chariottesville, VA 22908, USA aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/6(1996-06), 1051-1061 0305-7453 37:6<1051 1996 37 jac https://doi.org/10.1093/jac/37.6.1051 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.6.1051 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Townsend Gregory C. Department of Internal Medicine, Division of Infectious Diseases, University of Virginia, Chariottesville, VA 22908, USA aut NATIONALLICENCE 700 1- Scheld W. Michael Department of Internal Medicine, Division of Infectious Diseases, University of Virginia, Chariottesville, VA 22908, USA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/6(1996-06), 1051-1061 0305-7453 37:6<1051 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford