caa a22 4500 397593279 CHVBK 20180308164945.0 cr unu---uuuuu 161202e199604 xx s 000 0 eng 10.1093/jac/37.4.825 doi (NATIONALLICENCE)oxford-10.1093/jac/37.4.825 Zidovudine absorption and small intestinal function in HIV seropositive patients [Elektronische Daten] [K. Allan Macnab, M. J. Gill, L. R. Sutherland, R. Brant] Zidovudine absorption was evaluated in HIV seropositive patients with (n=15) and without diarrhoea (n=20) in a standardised prospective pharmacokinetic study using single oral 200 mg doses. Zidovudine was rapidly absorbed with large peak variation (Cmax: 1.10±0.43 mg/L). There were no significant associations between pharmacokinetic parameters and presence of diarrhoea, CD4 counts, red blood cell folate concentrations, stool cultures/leucocytes or the lactulose/mannitol absorption test. Mean diarrhoea AUC (mg/L.h) was 1.13±0.30 and 1.07±0.36 in non-diarrhoeal patients. Antidiarrhoeals increased AUC and Cmax values in a small, non statistically significant subset of diarrhoea patients. Although zidovudine absorption varies significantly, our data do not support dosage individualisation based on any of the above parameters. © 1996 The British Society for Antimicrobial Chemotherapy Brief reports nationallicence Macnab K. Allan Department of Family Medicine University of Calgary Calgary, Alberta; Canada aut Gill M. J. Department of Medicine University of Calgary Calgary, Alberta; Canada aut Sutherland L. R. Department of Medicine University of Calgary Calgary, Alberta; Canada aut Brant R. Department of Community Health Sciences, University of Calgary Calgary, Alberta; Canada aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 825-829 0305-7453 37:4<825 1996 37 jac https://doi.org/10.1093/jac/37.4.825 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.4.825 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Macnab K. Allan Department of Family Medicine University of Calgary Calgary, Alberta; Canada aut NATIONALLICENCE 700 1- Gill M. J. Department of Medicine University of Calgary Calgary, Alberta; Canada aut NATIONALLICENCE 700 1- Sutherland L. R. Department of Medicine University of Calgary Calgary, Alberta; Canada aut NATIONALLICENCE 700 1- Brant R. Department of Community Health Sciences, University of Calgary Calgary, Alberta; Canada aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 825-829 0305-7453 37:4<825 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford