caa a22 4500 397593392 CHVBK 20180308164945.0 cr unu---uuuuu 161202e199602 xx s 000 0 eng 10.1093/jac/37.2.275 doi (NATIONALLICENCE)oxford-10.1093/jac/37.2.275 Relative growth measurement of Candida species in a single concentration of fluconazole predicts the clinical response to fluconazole in HIV infected patients with oral candidosis [Elektronische Daten] [Jonathan D. Cartledge, Jenifer Midgley, Brain G. Gazzard] The growth of 113 Candida spp. isolated prospectively from 104 HIV-positive patients treated for thrush was determined using a single concentration of 3 mg/L (10−5M) fluconazole relative to growth in drug free medium. Using a receiver operator characteristic curve, a relative growth in fluconazole of ≥88% best discriminated between isolates from 56 patients who responded to treatment with fluconazole and 48 who failed to respond to 7 days, treatment with at least 100 mg/d drug with a sensitivity of 98% and a specificity of 96%. When the isolates from the eight patients with mixed infections due to both resistant and susceptible yeasts were excluded, the sensitivity and specificity both reached 100%. Relative growth of Candida spp. in a single concentration of fluconazole can therefore be used to accurately predict the clinical response to standard fluconazole treatment of thrush in patients infected with HIV. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Cartledge Jonathan D. Department of HIV/Genito-urinary Medicine, Chelsea & Westminster Health Care Trust, 369 Fulham Road, London SWW9NH, UK aut Midgley Jenifer Department of HIV/Genito-urinary Medicine, Chelsea & Westminster Health Care Trust, 369 Fulham Road, London SWW9NH, UK aut Gazzard Brain G. Department of HIV/Genito-urinary Medicine, Chelsea & Westminster Health Care Trust, 369 Fulham Road, London SWW9NH, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/2(1996-02), 275-283 0305-7453 37:2<275 1996 37 jac https://doi.org/10.1093/jac/37.2.275 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.2.275 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cartledge Jonathan D. Department of HIV/Genito-urinary Medicine, Chelsea & Westminster Health Care Trust, 369 Fulham Road, London SWW9NH, UK aut NATIONALLICENCE 700 1- Midgley Jenifer Department of HIV/Genito-urinary Medicine, Chelsea & Westminster Health Care Trust, 369 Fulham Road, London SWW9NH, UK aut NATIONALLICENCE 700 1- Gazzard Brain G. Department of HIV/Genito-urinary Medicine, Chelsea & Westminster Health Care Trust, 369 Fulham Road, London SWW9NH, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/2(1996-02), 275-283 0305-7453 37:2<275 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford