caa a22 4500 397593430 CHVBK 20180308164945.0 cr unu---uuuuu 161202e199612 xx s 000 0 eng 10.1093/jac/38.6.1001 doi (NATIONALLICENCE)oxford-10.1093/jac/38.6.1001 Optimising antimicrobial drug use in surgery: an intervention study in a Dutch university hospital [Elektronische Daten] [I. C. Gyssens, I. E. J. Geerligs, J. M. J. Dony, J. A. van der Vliet, A. van Kampen, P. J. van den Broek, Y. A. Hekster, J. W. M. van der Meer] Following a one-month prospective study of antimicrobial drug use in surgical departments, new guidelines were implemented. The review was repeated after two years. In both study periods, one third of patients were prescribed antimicrobial drugs. Prophylactic antibiotic consumption decreased from 0.75 to 0.53 defined daily doses/operation. Compliance with guidelines improved from 32% to 79%. Duration of prophylaxis > 24 h decreased from 21% to 8%. Single dose prophylaxis increased from 34% to 80%. Quality of the prophylactic courses improved, as evaluated by experts using established criteria. For prophylaxis, cost savings amounted to 57%. Better quality of therapeutic courses was associated with a cost increase of 15%. Indicators of satisfactory outcome with the new policy were a stable median length of stay (5.5 days in the first review and 5.0 days after intervention) and a reduction in the number of nosocomial infections treated with antimicrobial drugs/100 bed days (1.0 before intervention vs 0.77 after intervention). © 1996 by the British Society for Antimicrobial Chemotherapy Original articles nationallicence Gyssens I. C. Department of General Internal Medicine, University Hospital Nijmegen, and Department of Clinical Microbiology, University Hospital Rotterdam The Netherlands aut Geerligs I. E. J. Clinical Pharmacy, and General Internal Medicine, University Hospital Nijmegen The Netherlands aut Dony J. M. J. Departments of Obstetrics and Gynaecology The Netherlands aut van der Vliet J. A. Department of Surgery The Netherlands aut van Kampen A. Department of Orthopaedic Surgery The Netherlands aut van den Broek P. J. Department of Infectious Diseases, University Hospital Leiden The Netherlands aut Hekster Y. A. Clinical Pharmacy, and General Internal Medicine, University Hospital Nijmegen The Netherlands aut van der Meer J. W. M. Department of General Internal Medicine, University Hospital Nijmegen, and Department of Clinical Microbiology, University Hospital Rotterdam The Netherlands aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/6(1996-12), 1001-1012 0305-7453 38:6<1001 1996 38 jac https://doi.org/10.1093/jac/38.6.1001 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.6.1001 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gyssens I. C. Department of General Internal Medicine, University Hospital Nijmegen, and Department of Clinical Microbiology, University Hospital Rotterdam The Netherlands aut NATIONALLICENCE 700 1- Geerligs I. E. J. Clinical Pharmacy, and General Internal Medicine, University Hospital Nijmegen The Netherlands aut NATIONALLICENCE 700 1- Dony J. M. J. Departments of Obstetrics and Gynaecology The Netherlands aut NATIONALLICENCE 700 1- van der Vliet J. A. Department of Surgery The Netherlands aut NATIONALLICENCE 700 1- van Kampen A. Department of Orthopaedic Surgery The Netherlands aut NATIONALLICENCE 700 1- van den Broek P. J. Department of Infectious Diseases, University Hospital Leiden The Netherlands aut NATIONALLICENCE 700 1- Hekster Y. A. Clinical Pharmacy, and General Internal Medicine, University Hospital Nijmegen The Netherlands aut NATIONALLICENCE 700 1- van der Meer J. W. M. Department of General Internal Medicine, University Hospital Nijmegen, and Department of Clinical Microbiology, University Hospital Rotterdam The Netherlands aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/6(1996-12), 1001-1012 0305-7453 38:6<1001 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford