caa a22 4500 397593473 CHVBK 20180308164945.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/jac/38.5.865 doi (NATIONALLICENCE)oxford-10.1093/jac/38.5.865 Penetration of vancomycin into human lung tissue [Elektronische Daten] Vancomycin penetration into lung tissue was evaluated in thirty patients following the administration of 1 g of vancomycin as a 1 h iv infusion. Mean concentrations (range) of vancomycin in lung tissue were 9.6 (6.3-12.1) mg/kg at 1 h, 5.7 (4.7-7.4) mg/kg at 2 h, 4.2 (0.8-6.5) mg/kg at 3-4 h, 2.4 (1.4-4.7) mg/kg at 6 h, and 2.8 (0.9-7.8) mg/kg at 12 h after the end of infusion. Ratios of lung tissue to serum concentration ranged 0.24 to 0.41 at 1 and 12 h, respectively. One of six patients observed at 6 h, and 3 of 7 patients at 12 h did not have detectable levels of vancomycin in lung tissue. A 1 h iv infusion of a 1 g dose of vancomycin does not achieve sustained lung concentrations above the MIC for susceptible staphylococci over a dosing interval of 12 h. Therefore, a more appropriate modality of administration, such as continuous infusion, should be considered. © 1996 by the British Society for Antimicrobial Chemotherapy Brief reports nationallicence Cruciani M. Institute of Immunology and Infectious Diseases, Italy, Italy, Italy, Italy, Italy Gatti G. 1st Department of Infectious Diseases, School of Medicine, University of Genoa Italy Lazzarini L. Institute of Immunology and Infectious Diseases Italy Furlan G. Department of Thoracic Surgery Italy Broccali G. Institute of Clinical Chemistry, University of Verona Italy Malena M. Institute of Immunology and Infectious Diseases Italy Franchini C. Institute of Immunology and Infectious Diseases Italy Concia Ercole B. T. Biotecnica, Milan Italy Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 865-869 0305-7453 38:5<865 1996 38 jac https://doi.org/10.1093/jac/38.5.865 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.5.865 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cruciani M. Institute of Immunology and Infectious Diseases, Italy, Italy, Italy, Italy, Italy NATIONALLICENCE 700 1- Gatti G. 1st Department of Infectious Diseases, School of Medicine, University of Genoa Italy NATIONALLICENCE 700 1- Lazzarini L. Institute of Immunology and Infectious Diseases Italy NATIONALLICENCE 700 1- Furlan G. Department of Thoracic Surgery Italy NATIONALLICENCE 700 1- Broccali G. Institute of Clinical Chemistry, University of Verona Italy NATIONALLICENCE 700 1- Malena M. Institute of Immunology and Infectious Diseases Italy NATIONALLICENCE 700 1- Franchini C. Institute of Immunology and Infectious Diseases Italy NATIONALLICENCE 700 1- Concia Ercole B. T. Biotecnica, Milan Italy NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 865-869 0305-7453 38:5<865 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford