caa a22 4500 397593562 CHVBK 20180308164946.0 cr unu---uuuuu 161202e199604 xx s 000 0 eng 10.1093/jac/37.4.821 doi (NATIONALLICENCE)oxford-10.1093/jac/37.4.821 Concentrations of cefpodoxime in plasma, adenoid, and tonsillar tissue after repeated administrations of cefpodoxime proxetil in children [Elektronische Daten] [Theodore N. Bairamis, Thomas P. Nikolopoulos, Dimitrios A. Kafetzis, P. Begue, B. Lenfant, Dimitrios C. Kandiloros, Nickolas J. Apostolopopulos] Cefpodoxime proxetil was administered to 36 children undergoing tonsillectomy, adenoidectomy or both. It was very well tolerated. The detectable tissue concentrations of cefpodoxime were moderate but remained constant (approximately 0.05 mg/kg) 3, 6, and 12 h after the last dose of the drug, while the respective plasma concentrations were declining. This suggests the possibility of twice-daily administration. However, 30% of children did not have quantifiable concentrations in the tonsil and more than half the adenoids did not have quantifiable levels. Whether a higher dosage would lead to higher and more satisfactory tissue concentrations is a matter for further investigation. © 1996 The British Society for Antimicrobial Chemotherapy Brief reports nationallicence Bairamis Theodore N. E.N.T. and University Department of Pediatrics, P.&A. Kyriakou Children's Hospital Thibon and Lebadias, Athens 11527, Greece aut Nikolopoulos Thomas P. E.N.T. and University Department of Pediatrics, P.&A. Kyriakou Children's Hospital Thibon and Lebadias, Athens 11527, Greece aut Kafetzis Dimitrios A. E.N.T. and University Department of Pediatrics, P.&A. Kyriakou Children's Hospital Thibon and Lebadias, Athens 11527, Greece aut Begue P. Hopital A. Trousseau, Pathologie Infectieuse et Tropicale 8/28 Avenue du Dr. Arnold Netter, 75571 Paris, Cedex 12, France aut Lenfant B. Dept. of Pharmacokinetics and Metabolism Roussel Uclaf, 93230 Romainville, France aut Kandiloros Dimitrios C. Department of Otolaryngology—Head and Neck Surgery University of Athens, Ippokration General Hospital 114 Queen's Sofia Avenue Athens 11527 Greece aut Apostolopopulos Nickolas J. E.N.T. and University Department of Pediatrics, P.&A. Kyriakou Children's Hospital Thibon and Lebadias, Athens 11527, Greece aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 821-824 0305-7453 37:4<821 1996 37 jac https://doi.org/10.1093/jac/37.4.821 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.4.821 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bairamis Theodore N. E.N.T. and University Department of Pediatrics, P.&A. Kyriakou Children's Hospital Thibon and Lebadias, Athens 11527, Greece aut NATIONALLICENCE 700 1- Nikolopoulos Thomas P. E.N.T. and University Department of Pediatrics, P.&A. Kyriakou Children's Hospital Thibon and Lebadias, Athens 11527, Greece aut NATIONALLICENCE 700 1- Kafetzis Dimitrios A. E.N.T. and University Department of Pediatrics, P.&A. Kyriakou Children's Hospital Thibon and Lebadias, Athens 11527, Greece aut NATIONALLICENCE 700 1- Begue P. Hopital A. Trousseau, Pathologie Infectieuse et Tropicale 8/28 Avenue du Dr. Arnold Netter, 75571 Paris, Cedex 12, France aut NATIONALLICENCE 700 1- Lenfant B. Dept. of Pharmacokinetics and Metabolism Roussel Uclaf, 93230 Romainville, France aut NATIONALLICENCE 700 1- Kandiloros Dimitrios C. Department of Otolaryngology—Head and Neck Surgery University of Athens, Ippokration General Hospital 114 Queen's Sofia Avenue Athens 11527 Greece aut NATIONALLICENCE 700 1- Apostolopopulos Nickolas J. E.N.T. and University Department of Pediatrics, P.&A. Kyriakou Children's Hospital Thibon and Lebadias, Athens 11527, Greece aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/4(1996-04), 821-824 0305-7453 37:4<821 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford