caa a22 4500 397593619 CHVBK 20180308164946.0 cr unu---uuuuu 161202e199601 xx s 000 0 eng 10.1093/jac/37.1.77 doi (NATIONALLICENCE)oxford-10.1093/jac/37.1.77 Activity of CP 99,219 (trovafloxacin) compared with ciprofloxacin, sparfloxacin, clinafloxacin, lomefloxacin and cefuroxime against ten penicillin-susceptible and pencillin-resistant pneumococci by time-kill methodology [Elektronische Daten] [M. A. Visalli, M. R. Jacobs, P. C. Appelbaum] Activity of CP 99,219 (trovafloxacin), clinafloxacin, ciprofloxacin, sparfioxacin, lomefloxacin and cefuroxime against 4 penicillin-susceptible, 2 penicillin-intermedi ate and 4 penicillin-resistant pneumococci was tested by MIC and time-kill methodology. Bacteriostatic values for all three groups did not differ significantly with all compounds tested except cefuroxime, and were lowest for trovafloxacin and clinafloxacin, followed by sparfioxacin, ciprofloxacin and lomefloxacin; cefuroxime yielded values which increased in line with those of penicillin G. The test compounds were bactericidal (i.e. they reduced original counts by ≥log10 at one dilution above bacteriostatic levels) in most cases, though some strains showed slightly greater discrepancies between bacteriostatic and bactericidal levels of all compounds tested. Trovafloxacin, clinafloxacin and sparfioxacin yielded MIC and time-kill results which point to possible efficacy in treatment of penicillin-susceptible and -resistant pneumococcal infections. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Visalli M. A. Department of Pathology, Hershey Medical Center P.O. Box 850, Hershey, PA 17033 aut Jacobs M. R. Case Western Reserve University Cleveland, OH 44106, USA aut Appelbaum P. C. Department of Pathology, Hershey Medical Center P.O. Box 850, Hershey, PA 17033 aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/1(1996-01), 77-84 0305-7453 37:1<77 1996 37 jac https://doi.org/10.1093/jac/37.1.77 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.1.77 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Visalli M. A. Department of Pathology, Hershey Medical Center P.O. Box 850, Hershey, PA 17033 aut NATIONALLICENCE 700 1- Jacobs M. R. Case Western Reserve University Cleveland, OH 44106, USA aut NATIONALLICENCE 700 1- Appelbaum P. C. Department of Pathology, Hershey Medical Center P.O. Box 850, Hershey, PA 17033 aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/1(1996-01), 77-84 0305-7453 37:1<77 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford