caa a22 4500 397593686 CHVBK 20180308164946.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/jac/37.3.599 doi (NATIONALLICENCE)oxford-10.1093/jac/37.3.599 Effects of synthetic form of tracheal antimicrobial peptide on respiratory pathogens [Elektronische Daten] [Carl Lawyer, Sudha Pai, Misako Watabe, Haithem Bakir, Lanie Eagleton, Kounosuke Watabe] We have synthesized a C-terminal portion of tracheal antimicrobial peptide (TAP) with 38 amino acids and tested it for efficacy on various clinical isolates of Pseudomonas aeruginosa strains from patients with cystic fibrosis and also on Aspergillus fumigatus. Our results indicate that the synthetic TAP has both potent bactericidal and fungicidal activities and that a combination of TAP and amphotericin B showed strong additive effects of growth inhibition on A. fumigatus. These results suggest that TAP is potentially an effective therapy for Aspergillus and multi-drug-resistant Pseudomonas, pathogens that are often a serious threat to patients with cystic fibrosis. © 1996 The British Society for Antimicrobial Chemotherapy Brief reports nationallicence Lawyer Carl Department of Internal Medicine Pulmonary Division, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut Pai Sudha Department of Internal Medicine Pulmonary Division, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut Watabe Misako Department of Medical Microbiology and Immunology, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut Bakir Haithem Department of Internal Medicine Pulmonary Division, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut Eagleton Lanie Department of Internal Medicine Pulmonary Division, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut Watabe Kounosuke Department of Medical Microbiology and Immunology, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 599-604 0305-7453 37:3<599 1996 37 jac https://doi.org/10.1093/jac/37.3.599 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.3.599 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lawyer Carl Department of Internal Medicine Pulmonary Division, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut NATIONALLICENCE 700 1- Pai Sudha Department of Internal Medicine Pulmonary Division, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut NATIONALLICENCE 700 1- Watabe Misako Department of Medical Microbiology and Immunology, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut NATIONALLICENCE 700 1- Bakir Haithem Department of Internal Medicine Pulmonary Division, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut NATIONALLICENCE 700 1- Eagleton Lanie Department of Internal Medicine Pulmonary Division, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut NATIONALLICENCE 700 1- Watabe Kounosuke Department of Medical Microbiology and Immunology, School of Medicine, Southern Illinois University Springfield, Illinois 62702, USA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 599-604 0305-7453 37:3<599 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford