caa a22 4500 397593716 CHVBK 20180308164946.0 cr unu---uuuuu 161202e199605 xx s 000 0 eng 10.1093/jac/37.suppl_A.83 doi (NATIONALLICENCE)oxford-10.1093/jac/37.suppl_A.83 Comparative efficacy of sparfloxacin in comparison with amoxycillin plus ofloxacin in the treatment of community-acquired pneumonia [Elektronische Daten] [H. Portier, Th. May, A. Proust] A prospective, placebo controlled double-blind, randomised study comparing oral sparfloxacin 200 mg once daily following a 400 mg loading dose on day 1 with an oral combination of amoxycillin 1 g tid plus ofloxacin 200 mg bid was conducted in 211 hospitalised patients with community-acquired pneumonia. Patients were included in the study if they were aged > 65 years or had failed a previous course of antibacterial therapy. The duration of treatment was 10 days. The overall efficacy rates for the sparfloxacin and amoxycillin plus ofloxacin treatment groups were 91.9% and 81.5%, respectively, in evaluable patients at the end of treatment. Age or prior failure of antibacterial therapy did not affect the overall success rate of sparfloxacin. The safety profile of sparfloxacin was similar to that of the antibacterial combination. This study demonstrated that sparfloxacin given once daily is a suitable therapy for the treatment of community-acquired pneumonia in the elderly or in patients with failure of previous antibiotic therapy. © 1996 The British Society for Antimicrobial Chemotherapy Articles nationallicence Portier H. Hôpital du Bocage, Service des maladies infectieuses 2 Boulevard du Marechal de Lattre de Tassigny, 21034 Dijon aut May Th Hôpital CHU de Brabois, Service des maladies infectieuses rue Morvan, 54500 Vandoeuvre-Les-Nancy aut Proust A. Centre Hospitaller Gaston Doumergue, Service de pneumologie 5 rue Hoche, 30000 Nîmes, France aut Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-05), 83-91 0305-7453 37<83 1996 37 jac https://doi.org/10.1093/jac/37.suppl_A.83 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.suppl_A.83 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Portier H. Hôpital du Bocage, Service des maladies infectieuses 2 Boulevard du Marechal de Lattre de Tassigny, 21034 Dijon aut NATIONALLICENCE 700 1- May Th Hôpital CHU de Brabois, Service des maladies infectieuses rue Morvan, 54500 Vandoeuvre-Les-Nancy aut NATIONALLICENCE 700 1- Proust A. Centre Hospitaller Gaston Doumergue, Service de pneumologie 5 rue Hoche, 30000 Nîmes, France aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37(1996-05), 83-91 0305-7453 37<83 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford