caa a22 4500 397593805 CHVBK 20180308164946.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/jac/38.5.885 doi (NATIONALLICENCE)oxford-10.1093/jac/38.5.885 Development of guidelines for gentamicin dosing [Elektronische Daten] The performance of dosage guidelines for starting gentamicin therapy was evaluated prospectively in 50 patients with suspected or proven Gram-negative septicaemia and the results were compared with results from similar group of 50 patients for whom the guidelines were not followed. Peak concentrations were significantly higher when the guidelines were followed (7.2 (±1.9) mg/L vs 5.7 (±1.8) mg/L) but there was no difference in trough concentrations. Fifty-eight per cent of patients had both peak and trough concentrations within the target range (peak >5 mg/L, trough <2 mg/L) when doses were decided empirically; this increased to 96% when the guidelines were followed. However, use of the guidelines achieved peaks of >7 mg/L in only 56% of patients. A revised protocol with higher doses given less frequently was therefore developed and a prospective assessment of its performance indicated that satisfactory concentrations were obtained in 96% of patients. © 1996 by the British Society for Antimicrobial Chemotherapy Antimicrobial practice nationallicence Thomson A. H. Clinical Pharmacokinetics and Biometrics Unit, University Dept of Medicine and Therapeutics Glasgow G11 6NT, UK Duncan N. Pharmacy Practice Unit Glasgow G11 6NT, UK Silverstein B. Pharmacy Practice Unit Glasgow G11 6NT, UK Alcock S. Clinical Microbiology Department Glasgow G11 6NT, UK Jodrell D. Beatson Oncology Centre Glasgow G11 6NT, UK Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 885-893 0305-7453 38:5<885 1996 38 jac https://doi.org/10.1093/jac/38.5.885 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.5.885 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thomson A. H. Clinical Pharmacokinetics and Biometrics Unit, University Dept of Medicine and Therapeutics Glasgow G11 6NT, UK NATIONALLICENCE 700 1- Duncan N. Pharmacy Practice Unit Glasgow G11 6NT, UK NATIONALLICENCE 700 1- Silverstein B. Pharmacy Practice Unit Glasgow G11 6NT, UK NATIONALLICENCE 700 1- Alcock S. Clinical Microbiology Department Glasgow G11 6NT, UK NATIONALLICENCE 700 1- Jodrell D. Beatson Oncology Centre Glasgow G11 6NT, UK NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 885-893 0305-7453 38:5<885 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford