caa a22 4500 397593880 CHVBK 20180308164946.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/jac/38.3.499 doi (NATIONALLICENCE)oxford-10.1093/jac/38.3.499 Pharmacokinetics of once-a-day netilmicin (6 mg/kg) in neonates [Elektronische Daten] [J. J. Ettiinger, K. A. Bedford, A. M. Loveriog, D. S. Reeves, B. D. Speidel, A. P. MacGowan] The pharmacokinetics of once a day netilmicin (6 mg/kg) was studied in 21 neonates. The babies were divided into three groups according to gestational age: group I aged >36 weeks; group II between 34-36 weeks and group III <34 weeks. Serum concentrations were variable between patients and the concentration 24 h after the first dose ranged from 0.8 to 3.8 mg/L with only two babies having concentrations of < 1 mg/L while seven had concentrations of > 2 mg/L. There were also large patient-to-patient variations in serum half-life, volume of distribution, area under the curve and relative plasma clearance such that these parameters could not be correlated to gestational age or weight. Absolute plasma clearance was correlated with both gestational age and weight. There was evidence of accumulation between the first and second dose for all three patient groups and for patients of gestational age < 34 weeks (group III) these observations were statistically significant. A netilmicin dosage of 4.5 mg/kg once a day may be more suitable for all neonates supported by assay of serum concentrations. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Ettiinger J. J. Department of Neonatal Medicine aut Bedford K. A. Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust and the University of Bristol, Department of Medical Microbiology, Southmead Hospital Westbury-on-Trym, Bristol, BSW 5NB, UK aut Loveriog A. M. Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust and the University of Bristol, Department of Medical Microbiology, Southmead Hospital Westbury-on-Trym, Bristol, BSW 5NB, UK aut Reeves D. S. Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust and the University of Bristol, Department of Medical Microbiology, Southmead Hospital Westbury-on-Trym, Bristol, BSW 5NB, UK aut Speidel B. D. Department of Neonatal Medicine aut MacGowan A. P. Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust and the University of Bristol, Department of Medical Microbiology, Southmead Hospital Westbury-on-Trym, Bristol, BSW 5NB, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 499-505 0305-7453 38:3<499 1996 38 jac https://doi.org/10.1093/jac/38.3.499 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.3.499 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ettiinger J. J. Department of Neonatal Medicine aut NATIONALLICENCE 700 1- Bedford K. A. Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust and the University of Bristol, Department of Medical Microbiology, Southmead Hospital Westbury-on-Trym, Bristol, BSW 5NB, UK aut NATIONALLICENCE 700 1- Loveriog A. M. Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust and the University of Bristol, Department of Medical Microbiology, Southmead Hospital Westbury-on-Trym, Bristol, BSW 5NB, UK aut NATIONALLICENCE 700 1- Reeves D. S. Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust and the University of Bristol, Department of Medical Microbiology, Southmead Hospital Westbury-on-Trym, Bristol, BSW 5NB, UK aut NATIONALLICENCE 700 1- Speidel B. D. Department of Neonatal Medicine aut NATIONALLICENCE 700 1- MacGowan A. P. Bristol Centre for Antimicrobial Research & Evaluation, Southmead Health Services NHS Trust and the University of Bristol, Department of Medical Microbiology, Southmead Hospital Westbury-on-Trym, Bristol, BSW 5NB, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 499-505 0305-7453 38:3<499 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford