caa a22 4500 397593902 CHVBK 20180308164947.0 cr unu---uuuuu 161202e199609 xx s 000 0 eng 10.1093/jac/38.3.425 doi (NATIONALLICENCE)oxford-10.1093/jac/38.3.425 Multi-drug resistant non-typhi salmonellae in Kenya [Elektronische Daten] [S. Kariaki, C. Gilks, J. Corkill, J. Kimari, A. Benea, P. Waiyaki, C. A. Hart] Two methods of plasmid characterization, restriction digest patterns and incompatibility grouping, were used to study self-transmissible multi-drug resistance among non-typhi salmonellae (NTS). Resistance to ampicillin and other commonly applied β-lactams was evaluated by iso-electric focusing and disc inactivation. Of the NTS isolated from blood, 75% were Salmonella typhimurium but those included several different phage types. Over 47% of isolates were resistant to three or more of the readily available drugs including ampicillin, cefuroxime, chloramphenicol, co-trimoxazole, streptomycin and tetracycline. Self-transferable resistance plasmids (c. 100 kb) were essentially of incompatibility group incFIIA, but their restriction fragment patterns revealed a diversity in relatedness. More than half of parent strains and their transconjugants produced β-lactamases which co-electrophoresed with TEM-1 and OXA-1. This study has observed a disturbingly high prevalence of transmissible multi-drug resistance among NTS which are an important cause of morbidity in HIV-1 seropositive individuals. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Kariaki S. Department of Medical Microbiology and Genito-Urinary Medicine aut Gilks C. School of Tropical Medicine, University of Liverpool PO Box 147, Liverpool, L69 4BX UK aut Corkill J. Department of Medical Microbiology and Genito-Urinary Medicine aut Kimari J. Centre for Microbiology Research, Kenya Medical ResearchInstitute PO Box 54840, Nairobi, Kenya aut Benea A. Centre for Microbiology Research, Kenya Medical ResearchInstitute PO Box 54840, Nairobi, Kenya aut Waiyaki P. Centre for Microbiology Research, Kenya Medical ResearchInstitute PO Box 54840, Nairobi, Kenya aut Hart C. A. Centre for Microbiology Research, Kenya Medical ResearchInstitute PO Box 54840, Nairobi, Kenya aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 425-434 0305-7453 38:3<425 1996 38 jac https://doi.org/10.1093/jac/38.3.425 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.3.425 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kariaki S. Department of Medical Microbiology and Genito-Urinary Medicine aut NATIONALLICENCE 700 1- Gilks C. School of Tropical Medicine, University of Liverpool PO Box 147, Liverpool, L69 4BX UK aut NATIONALLICENCE 700 1- Corkill J. Department of Medical Microbiology and Genito-Urinary Medicine aut NATIONALLICENCE 700 1- Kimari J. Centre for Microbiology Research, Kenya Medical ResearchInstitute PO Box 54840, Nairobi, Kenya aut NATIONALLICENCE 700 1- Benea A. Centre for Microbiology Research, Kenya Medical ResearchInstitute PO Box 54840, Nairobi, Kenya aut NATIONALLICENCE 700 1- Waiyaki P. Centre for Microbiology Research, Kenya Medical ResearchInstitute PO Box 54840, Nairobi, Kenya aut NATIONALLICENCE 700 1- Hart C. A. Centre for Microbiology Research, Kenya Medical ResearchInstitute PO Box 54840, Nairobi, Kenya aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/3(1996-09), 425-434 0305-7453 38:3<425 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford