caa a22 4500 39759397X CHVBK 20180308164947.0 cr unu---uuuuu 161202e199603 xx s 000 0 eng 10.1093/jac/37.3.545 doi (NATIONALLICENCE)oxford-10.1093/jac/37.3.545 Pharmacokinetics of a single dose of teicoplanin in burn patients [Elektronische Daten] [J. A. Steer, R. P. G. Papini, A. P. R. Wilson, S. Dhillon, M. F. Hichens, D. A. McGrouther, J. D. Frame, N. Parkhouse] Patients with severe bums are susceptible to infection with Gram-positive organisms including methicillin-resistant Staphylococcus aureus, and often require higher antibiotic dosages compared with other patients. This study examined the pharmacokinetics of a single iv dose of teicoplanin (12 mg/kg) in 15 adults and five children with severe burns. Adults were aged 21-82 years with a median total body surface area (TBSA) burn of 30% (range 15-60%). Children were aged 10 months-10 years with median TBSA burn of 15% (10-30%). At 12 h, the median serum teicoplanin concentration was 12.8 mg/L (9.0-27.1 mg/L) in adults and 7.6 mg/L (6.6-10.8 mg/L) in children, (P < 0.01); at 24 h, the corresponding values were 8.3 mg/L (4.6-12.9 mg/L) and 5.2 mg/L (4.2-6.0 mg/L). Using a three-compartment model, the median terminal half life in adults was 114 h (47-278 h). Children fitted a two-compartment model with a terminal half-life of 38 h (21-41 h). The median concentration of teicoplanin in fluid from the burn wound was 60% of the serum antibiotic concentration. A single iv dose of 12 mg/kg of teicoplanin was sufficient to produce therapeutic serum concentrations in burn patients for 24 h, but monitoring of antibiotic levels in serum may be advisable in those with high total clearance, especially children. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Steer J. A. Departments of Microbiology, University College London Hospitals London aut Papini R. P. G. Departments of Microbiology, University College London Hospitals London aut Wilson A. P. R. Departments of Microbiology, University College London Hospitals London aut Dhillon S. School of Pharmacy, Univerity of London Billericay, Essex aut Hichens M. F. Departments of Microbiology, University College London Hospitals London aut McGrouther D. A. Plastic Surgery, Univeristy College London Hospitals London aut Frame J. D. Department of Plastic Surgery, St. Andrew's Hospital Billericay, Essex aut Parkhouse N. RAFT Department of Plastic Surgery, Mount Vernon Hospital Northwood, Middlesex, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 545-553 0305-7453 37:3<545 1996 37 jac https://doi.org/10.1093/jac/37.3.545 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.3.545 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Steer J. A. Departments of Microbiology, University College London Hospitals London aut NATIONALLICENCE 700 1- Papini R. P. G. Departments of Microbiology, University College London Hospitals London aut NATIONALLICENCE 700 1- Wilson A. P. R. Departments of Microbiology, University College London Hospitals London aut NATIONALLICENCE 700 1- Dhillon S. School of Pharmacy, Univerity of London Billericay, Essex aut NATIONALLICENCE 700 1- Hichens M. F. Departments of Microbiology, University College London Hospitals London aut NATIONALLICENCE 700 1- McGrouther D. A. Plastic Surgery, Univeristy College London Hospitals London aut NATIONALLICENCE 700 1- Frame J. D. Department of Plastic Surgery, St. Andrew's Hospital Billericay, Essex aut NATIONALLICENCE 700 1- Parkhouse N. RAFT Department of Plastic Surgery, Mount Vernon Hospital Northwood, Middlesex, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/3(1996-03), 545-553 0305-7453 37:3<545 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford