caa a22 4500 397594011 CHVBK 20180308164947.0 cr unu---uuuuu 161202e199612 xx s 000 0 eng 10.1093/jac/38.6.927 doi (NATIONALLICENCE)oxford-10.1093/jac/38.6.927 Effects of omeprazole and amoxycillin on the human oral and gastrointestinal microflora in patients with Helicobacter pylori infection [Elektronische Daten] [C. A. Stark, I. Adamsson, C. Edlund, S. Sjösted, R. Seensalu, B. Wikström, C. E. Nord] Fourteen patients with Helicobacter pylori infection were treated with omeprazole capsules 20 mg and amoxycillin capsules 1000 mg twice daily for 14 days and 14 patients with omeprazole capsules 20 mg and placebo twice daily for 14 days Samples from saliva, dental plaque and faeces and biopsies from antrum and corpus were analysed in order to determine the ecological changes in the normal microflora. Several microorganisms were affected by both treatment regimens. Two patients were colonised with enterobacteria in the oral cavity and stomaćh during the omeprazole plus amoxycillin treatment. A general increase in the number of microorganisms from gastric mucosa was observed in both treatment groups. A selection of resistant enterobacteria and an increase in β-lactamase production was observed in the faecal samples during the omeprazole plus amoxycillin treatment. Eradication of H. pylori in the omeprazole-amoxycillin group was 50% and in the omeprazole-placebo group 0% four weeks after treatment. No viable H. pylori were cultivated in the saliva, dental plaque or faecal samples. Treatment with omeprazole 20 mg and amoxycillin 1000 mg twice daily for 14 days altered the normal microflora in the oral, gastric and intestinal tract and antibiotic resistant microorganisms increased in numbers in the intestinal microflora. © 1996 by the British Society for Antimicrobial Chemotherapy Original articles nationallicence Stark C. A. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut Adamsson I. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut Edlund C. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut Sjösted S. Department of Surgery, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut Seensalu R. Department of Surgery, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut Wikström B. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut Nord C. E. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/6(1996-12), 927-939 0305-7453 38:6<927 1996 38 jac https://doi.org/10.1093/jac/38.6.927 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.6.927 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stark C. A. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut NATIONALLICENCE 700 1- Adamsson I. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut NATIONALLICENCE 700 1- Edlund C. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut NATIONALLICENCE 700 1- Sjösted S. Department of Surgery, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut NATIONALLICENCE 700 1- Seensalu R. Department of Surgery, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut NATIONALLICENCE 700 1- Wikström B. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut NATIONALLICENCE 700 1- Nord C. E. Department of Immunology, Microbiology, Pathology and Infectious Diseases, Huddinge University Hospital, Karolinska Institute Stockholm, Sweden aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/6(1996-12), 927-939 0305-7453 38:6<927 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford