caa a22 4500 397594038 CHVBK 20180308164947.0 cr unu---uuuuu 161202e199602 xx s 000 0 eng 10.1093/jac/37.2.253 doi (NATIONALLICENCE)oxford-10.1093/jac/37.2.253 The effect of antibiotics on bacteria under hyperbaric conditions [Elektronische Daten] [J. Hind, R. W. Attwell] The sensitivity of selected bacteria to a range of antibiotics was tested under hyperbaric conditions used in saturation diving. The effect of hyperbaric helium and oxygen (heliox) on antibiotic stability and on induction of β-lactamase was also determined. Increased resistance to penicillin (up to 23%) was shown by Staphylococcus aureus and to gentamicin (up to 46%) and rifampicin (up to 18%) by Escherichia coli and Salmonella typhimurium at 36 and 71 bar pressure. Exposure to 71 bar heliox did not affect antibiotic activity but increased the production of β-lactamase in inducible S. aureus and Bacillus subtilis and production of β-galactosidase in inducible E. coli. Increased resistance to antibiotics in saturation diving conditions can be attributed in some cases to the influence of hyperbaric pressure on induction mechanisms in bacteria. The experimental system devised for this work is suitable for more detailed examination of the influence of hyperbaric stress on antibiotic resistance and of its effect on induction mechanisms in general. © 1996 The British Society for Antimicrobial Chemotherapy Original articles nationallicence Hind J. University of Maryland, Center of Marine Biotechnology 600 E. Lombard Street, Baltimore, Maryland 21202, USA aut Attwell R. W. Department of Biological Sciences, Manchester Metropolitan University Chester Street, Manchester Ml 5GD, UK aut Journal of Antimicrobial Chemotherapy Oxford University Press 37/2(1996-02), 253-263 0305-7453 37:2<253 1996 37 jac https://doi.org/10.1093/jac/37.2.253 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/37.2.253 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hind J. University of Maryland, Center of Marine Biotechnology 600 E. Lombard Street, Baltimore, Maryland 21202, USA aut NATIONALLICENCE 700 1- Attwell R. W. Department of Biological Sciences, Manchester Metropolitan University Chester Street, Manchester Ml 5GD, UK aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 37/2(1996-02), 253-263 0305-7453 37:2<253 1996 37 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford