caa a22 4500 397594062 CHVBK 20180308164947.0 cr unu---uuuuu 161202e199611 xx s 000 0 eng 10.1093/jac/38.5.809 doi (NATIONALLICENCE)oxford-10.1093/jac/38.5.809 Aerosolization of imipenem/cilastatin prevents pseudomonas-induced acute lung injury [Elektronische Daten] [S. Hashimoto, E. Wolfe, B. Guglielmo, R. Shanks, J. Sundelof, J. F. Pittet, E. Thomas, J. Wiener-Kronish] Aerosolization of imipenem/cilastatin was compared with continuous intravenous infusions of the antibiotic for pharrnacokinetic/pharmacodynarnic analysis. The concentrations of imipenim/cilastatin in bronchoalveolar lavage fluids (BAL) obtained from rats exposed to the aerosolized antibiotic were significantly greater than the concentrations in BAL in the rats that had received intravenous infusions of imipenem/cilastatin. The two methods of antibiotic delivery were compared for their effects on bacterial-induced lung injury in rats that had Pseudomonas aeruginosa instilled into their airspaces. The aerosolization of antibiotic was associated with significantly decreased bacterial-induced lung injury. The high concentrations of antibiotic in the airspaces secondary to aerosolization appears to kill bacteria more quickly and preserve lung epithelial and endothelial integrity better than systemic delivery of the same antibiotic. © 1996 by the British Society for Antimicrobial Chemotherapy Original articles nationallicence Hashimoto S. Department of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine Kyoto Japan 602 Wolfe E. Division of Clinical Pharmacy, University of California at San Francisco CA aut Guglielmo B. Division of Clinical Pharmacy, University of California at San Francisco CA aut Shanks R. Department of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine Kyoto Japan 602 aut Sundelof J. Merck Research Lab Rahway, NJ, USA aut Pittet J. F. Department of Anesthesia and Medicine, University of California at San Francisco CA aut Thomas E. Department of Anesthesia and Medicine, University of California at San Francisco CA aut Wiener-Kronish J. Department of Anesthesia and Medicine, University of California at San Francisco CA aut Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 809-818 0305-7453 38:5<809 1996 38 jac https://doi.org/10.1093/jac/38.5.809 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1093/jac/38.5.809 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hashimoto S. Department of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine Kyoto Japan 602 NATIONALLICENCE 700 1- Wolfe E. Division of Clinical Pharmacy, University of California at San Francisco CA aut NATIONALLICENCE 700 1- Guglielmo B. Division of Clinical Pharmacy, University of California at San Francisco CA aut NATIONALLICENCE 700 1- Shanks R. Department of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine Kyoto Japan 602 aut NATIONALLICENCE 700 1- Sundelof J. Merck Research Lab Rahway, NJ, USA aut NATIONALLICENCE 700 1- Pittet J. F. Department of Anesthesia and Medicine, University of California at San Francisco CA aut NATIONALLICENCE 700 1- Thomas E. Department of Anesthesia and Medicine, University of California at San Francisco CA aut NATIONALLICENCE 700 1- Wiener-Kronish J. Department of Anesthesia and Medicine, University of California at San Francisco CA aut NATIONALLICENCE 773 0- Journal of Antimicrobial Chemotherapy Oxford University Press 38/5(1996-11), 809-818 0305-7453 38:5<809 1996 38 jac Metadata rights reserved CC BY-NC-4.0 http://creativecommons.org/licenses/by-nc/4.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-oxford