caa a22 4500 445292830 CHVBK 20180317142533.0 cr unu---uuuuu 170323e20100901xx s 000 0 eng 10.1007/s11626-010-9329-8 doi (NATIONALLICENCE)springer-10.1007/s11626-010-9329-8 Effect of PP-2A on neurite outgrowth in neuronal cells [Elektronische Daten] [Dan Liu, Hong-Yun Zheng, Zheng-Zhao Luo, Qun Wang, Ling-Qiang Zhu] Protein phosphatase 2A (PP-2A) has been implicated to be crucial in neural development and the normal function of nervous system. However, little is known about its role in neuritogenesis. In this study, we reported that inhibition of PP-2A strongly suppresses the outgrowth of cell processes only during the initiation stage, while activation of PP-2A promotes extensive outgrowth of long neurites in Neura2A cells and long single axon or multiple axons in hippocampal neurons. Our results indicated that PP-2A may be an important positive regulator in neurite outgrowth, and upregulation PP-2A could be a possible target for the therapy of axonopathy in neural diseases. The Society for In Vitro Biology, 2010 Neurite nationallicence Axon outgrowth nationallicence PP-2A nationallicence Neuron nationallicence Liu Dan Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People's Republic of China aut Zheng Hong-Yun Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People's Republic of China aut Luo Zheng-Zhao Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People's Republic of China aut Wang Qun Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People's Republic of China aut Zhu Ling-Qiang Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People's Republic of China aut In Vitro Cellular & Developmental Biology - Animal Springer-Verlag 46/8(2010-09-01), 702-707 1071-2690 46:8<702 2010 46 11626 https://doi.org/10.1007/s11626-010-9329-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11626-010-9329-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Dan Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Zheng Hong-Yun Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Luo Zheng-Zhao Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Wang Qun Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Zhu Ling-Qiang Department of Pathophysiology, Institute of Neuroscience, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, People's Republic of China aut NATIONALLICENCE 773 0- In Vitro Cellular & Developmental Biology - Animal Springer-Verlag 46/8(2010-09-01), 702-707 1071-2690 46:8<702 2010 46 11626 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer