caa a22 4500 445293039 CHVBK 20180317142534.0 cr unu---uuuuu 170323e20100201xx s 000 0 eng 10.1007/s11626-009-9252-z doi (NATIONALLICENCE)springer-10.1007/s11626-009-9252-z Establishment and characterization of human bladder cancer cell lines BexBra1, BexBra2, and BexBra4 [Elektronische Daten] [Camila Piantino, Juliana Sousa-Canavez, Victor Srougi, Fernanda Salvadori, Raphael Kato, Pedro Ayres, Miguel Srougi, Luiz Camara-Lopes, Gilka Gattás, Cintia Fridman, Fernanda de Toledo, Isaque Santana, Kátia Leite] Bladder cancer (BC) is the fourth most common cancer in the USA. In Brazil, BC represents 3% of the total existing carcinomas in the population and represents the second highest incidence among urological tumors. The majority of bladder cancer cell lines available were derived from Caucasians and established in the seventies or eighties. Thus, neoplasia development in these cells likely occurred in environment conditions vastly different than today. In the present study, we report the establishment and characterization of three Brazilian bladder cancer cell lines (BexBra1, BexBra2, and BexBra4). These cell lines may be helpful for dissecting the genetic and epigenetic aspects that trigger the progression of BC. Moreover, the development of a Brazilian representative of the disease will allow us to investigate the potential inter-racial differences of malignancy-associated phenotypes in bladder cancer. The Society for In Vitro Biology, 2009 Bladder cancer nationallicence Establishment nationallicence Cell lines nationallicence Piantino Camila Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut Sousa-Canavez Juliana Genoa Biotechnology SA, Rua Desembargador Eliseu Guilherme 69, 9th floor, 04004-030, São Paulo, São Paulo, Brazil aut Srougi Victor Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut Salvadori Fernanda Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut Kato Raphael Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut Ayres Pedro Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut Srougi Miguel Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut Camara-Lopes Luiz Genoa Biotechnology SA, Rua Desembargador Eliseu Guilherme 69, 9th floor, 04004-030, São Paulo, São Paulo, Brazil aut Gattás Gilka Laboratory of Medical Investigation, Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo Medical School, São Paulo, São Paulo, Brazil aut Fridman Cintia Laboratory of Medical Investigation, Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo Medical School, São Paulo, São Paulo, Brazil aut de Toledo Fernanda Laboratory of Medical Investigation, Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo Medical School, São Paulo, São Paulo, Brazil aut Santana Isaque Genoa Biotechnology SA, Rua Desembargador Eliseu Guilherme 69, 9th floor, 04004-030, São Paulo, São Paulo, Brazil aut Leite Kátia Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut In Vitro Cellular & Developmental Biology - Animal Springer-Verlag 46/2(2010-02-01), 131-139 1071-2690 46:2<131 2010 46 11626 https://doi.org/10.1007/s11626-009-9252-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11626-009-9252-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Piantino Camila Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Sousa-Canavez Juliana Genoa Biotechnology SA, Rua Desembargador Eliseu Guilherme 69, 9th floor, 04004-030, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Srougi Victor Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Salvadori Fernanda Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Kato Raphael Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Ayres Pedro Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Srougi Miguel Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Camara-Lopes Luiz Genoa Biotechnology SA, Rua Desembargador Eliseu Guilherme 69, 9th floor, 04004-030, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Gattás Gilka Laboratory of Medical Investigation, Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo Medical School, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Fridman Cintia Laboratory of Medical Investigation, Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo Medical School, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- de Toledo Fernanda Laboratory of Medical Investigation, Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo Medical School, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Santana Isaque Genoa Biotechnology SA, Rua Desembargador Eliseu Guilherme 69, 9th floor, 04004-030, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Leite Kátia Laboratory of Medical Investigation, Urology Department-LIM55, University of Sao Paulo Medical School, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 773 0- In Vitro Cellular & Developmental Biology - Animal Springer-Verlag 46/2(2010-02-01), 131-139 1071-2690 46:2<131 2010 46 11626 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer